白内障晶状体上皮细胞的超微结构观察  

Observation on the ultrastructure of cataract lens epithelial cells

作　　者：喻建锋[1] 宋愈[1] 吴莹[1] 黄黎黎[1] 

机构地区：[1]南通市第一人民医院眼科,江苏省南通 226001

出　　处：《中国基层医药》2013年第10期1500-1501,I0001,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察老年性白内障与糖尿病性白内障晶状体上皮细胞的超微结构,探讨晶状体上皮细胞凋亡及自噬与白内障的关系。方法 用透射电镜观察5例老年性白内障及5例糖尿病性白内障晶状体上皮细胞的超微结构,并与2例透明晶状体上皮细胞的超微结构相比较。结果 老年性白内障及糖尿病性白内障晶状体上皮细胞中可见细胞凋亡现象及自噬现象,而正常晶状体上皮细胞中未见凋亡及自噬现象。结论 老年性白内障及糖尿病性白内障的发生、发展与晶状体上皮细胞凋亡及细胞自噬密切相关。Objective To study the relationship of cataract with lens epithelial cell apoptosis and autophagy by observing the ultrastructure of age-related and diabetic cataract lens epithelial cells.Methods Transmission electron microscope was used to observe the apoptotic and autophagic morphology of the lens epithelial cells in 5 cases with age-related and diabetic cataract respectively,and in 2 cases with normal lens.Results The apoptosis and autophagy of lens epithelial cells was found in cases with age-related and diabetic cataract,while no expression was observed in control lens epithelial cells.Conclusion The apoptosis and autophagy of lens epithelial cells are closely related to age-related and diabetic cataract formation.

关 键 词：白内障 晶状体上皮细胞 凋亡 自噬 

分 类 号：R776.1[医药卫生—眼科]