唾液蛋白变化与患龋风险的相关性分析  

The relationship between salivary protein's change and dental caries

作　　者：杨柳青[1] 孙青[1] 魏辰轩[1] 王晓丽[1] 

机构地区：[1]上海交通大学附属第一人民医院口腔科,上海200080

出　　处：《上海口腔医学》2013年第2期198-201,共4页Shanghai Journal of Stomatology

基　　金：上海市科学技术委员会资助项目(081411967000)~~

摘　　要：目的:分析服用糖皮质激素(GC)后唾液蛋白含量变化对龋齿的影响。方法:设试验组和对照组各30例,收集试验组服用GC前(T1)和服用后(T2)及正常对照组首次(C1)和12个月后(C2)混合唾液样本,检测其中溶菌酶(LZM)、免疫球蛋白A(IgA)、乳酸脱氢酶(LDH)的含量;检查2组患龋情况并计算龋失补牙面数、龋失补牙数、龋蚀指数。采用SPSS17.0软件包对结果数据进行统计学分析。结果:服用GC后,LZM、IgA含量显著低于正常组(P<0.01),LDH含量显著高于正常组(P<0.01)。服用GC前后,唾液蛋白的变化与龋失补牙面数、龋失补牙数、龋蚀指数显著相关。结论:服用GC后,LZM、IgA、LDH含量发生改变。LZM、IgA、LDH作为口腔重要的免疫成分,参与龋齿的发生、发展过程。PURPOSE： To evaluate the relationship between salivary protein＇s change and dental caries in patients after oral administration of glucocorticoid. METHODS： Sixty patients were divided equally into the experimental group and the control group. The mixed saliva samples of the experimental group before （T1） and after （T2） taking GC orally, as well as the baseline （C1） and after 12 months （C2） of the control group were collected. IgA, LDH, LZM were examined in both groups. The decayed-missing-filled surface （DMFS）, decayed-missing-filled tooth （DMFT）, caries severity index （CSI） in both groups were recorded. All statistical analyses were performed using SPSS17.0 software package. RESULTS： After taking GC orally, the concentration of IgA and LZM were significantly lower than the control group （P〈0.01）, while the concentration of LDH was significantly higher than the control group （P〈0.01）. Before and after taking GC orally, the salivary protein＇s change was significantly correlated with DMFT,DMFS and CSI. CONCLUSIONS： After taking glucocorticoid orally, the concentration of LZM, IgA, LDH in saliva changes. LZM, IgA, LDH take part in the occurrence and development of dental caries as the important part of oral immunization. Supported by Research Fund of Science and Technology Commission of Shanghai Municipality（081411967000）.

关 键 词：唾液蛋白 龋病指数 龋齿 糖皮质激素 

分 类 号：R781.1[医药卫生—口腔医学]