血管周细胞在肿瘤血管生成和转移过程中的作用研究进展  

Role of pericytes during tumor angiogenesis and metastasis

作　　者：邓鑫[1] 罗茂[1] 李蓉[1] 吴剑波[1] 

机构地区：[1]泸州医学院药物与功能性食品研究中心,四川省泸州市646000

出　　处：《中国肿瘤临床》2013年第8期483-485,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:81172050)资助~~

摘　　要：大量研究证明肿瘤的生长和转移与肿瘤血管生成密切相关。血管周细胞作为血管组织的重要组成部分,在血管新生以及维持血管稳定中发挥重要作用。作为一种血管周基质细胞,血管周细胞能为血管提供结构支持以及通过影响血管稳定性来调整局部组织生理环境。尽管目前血管周细胞在癌症病理机制中的作用还不完全清楚,但大量研究结果揭示血管周细胞-内皮细胞信号网络的失常对肿瘤血管生成和转移有重要意义。本文旨在评价关于血管周细胞在肿瘤病理机制方面的重要研究成果以及探讨潜在的抗癌治疗靶点。A large number of studies have demonstrated that the growth and metastasis of tumors are closely correlated with tu- mor angiogenesis. Pericytes are an important part of the vascular tissues, which play a significant role in angiogenesis and vascular sta- bility. As perivascular stromal cells, pericytes can provide structural support to the blood vessels and regulate local physiological envi- ronment via its influence on the vascular stability. Although the fimctional role of pericytes in cancer progression remains unclear, nu- merous studies have indicated that the aberrations in the pericyte - endothelial cell signaling networks could contribute significantly on tumor angiogenesis and metastasis. This review aims to critically evaluate the results of a recent study on the functional role of pericytes in tumor pathophysiology and discuss potential therapeutic targets for anticancer intervention.

关 键 词：血管周细胞 血管生成 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]