Ki-67表达对“三阴性”乳腺癌新辅助化疗疗效影响  被引量:9

The Influence of Ki-67 Expression on Triple-negative Breast Cancer with Neo-adjuvant Chemotherapy

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作  者:叶国麟[1,2] 杨劼[1,2] 古卫权[1,2] 潘瑞琳[1,2] 廖富毅[1,2] 叶俊[1,2] 朱乐伟[1,2] 王飞[1,2] 杨胜利[1,2] 

机构地区:[1]中山大学附属佛山医院 [2]广东省佛山市第一人民医院胸外科,广东佛山528000

出  处:《河北医学》2013年第6期832-834,共3页Hebei Medicine

摘  要:目的:探讨"三阴性"乳腺癌Ki-67表达对新辅助化疗疗效的预测价值,有助于乳腺癌治疗的选择及预后。方法:对74例分别实施TEC及CEF方案新辅助化疗的"三阴性"乳腺癌病例进行回顾性分析,应用免疫组化法检测化疗前后Ki-67表达,分析Ki-67表达与疗效关系。结果:Ki-67高表达患者接受CET新辅助化疗化疗PCR率更高。结论:Ki-67的高表达可以作为"三阴性"乳腺癌CET方案化疗疗效预测指标。Objective: To explore the influence of Ki-67 expression in triple-negative breast cancer to the predictive value of neo-adjuvant chemotherapy, and to assist selecting of treatment methods and progno- sis of breast cancer. Methods: Retrospective analysis was carried out in 74 patients with triple- negative breast cancer who underwent TEC and CEF neo-adjuvant chemotherapy regimens, and the expression of Ki- 67 was investigated by immunohistochemistry. In addition, the relation between Ki-67 expression and treat- ment effect was also analyzed. Result: PCR rate was detected high in patients with high Ki-67. expression. Conclusions:High Ki-67 expression can be regarded as the predictive index of CEF chemotherapy regimen in triple-negative breast cancer.

关 键 词:乳腺癌 新辅助化疗 KI-67 

分 类 号:R737.9[医药卫生—肿瘤]

 

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