薄膜蒸发法制备吲哚美辛醇质体的方法优化  

Preparation of Indomethacin ethosomes by film dispersion method

作　　者：傅秀娟[1] 任美萍[2] 钟志容[1] 王芳[1] 

机构地区：[1]泸州医学院药学院 [2]泸州医学院药物与功能性食品研究中心,四川泸州646000

出　　处：《泸州医学院学报》2013年第2期129-133,共5页Journal of Luzhou Medical College

基　　金：泸州市科技局项目(2011-161)

摘　　要：目的:优化薄膜蒸发法制备吲哚美辛醇质体的工艺参数。方法:采用正交试验设计,考察了药物的量、磷脂用量、乙醇浓度、搅拌时间等影响因素,并以包封率作为评价指标,利用SPSS11.5对结果进行分析,筛选出最佳工艺。结果:最佳工艺为取吲哚美辛0.15g,加入0.5g磷脂,用氯仿10ml溶解,蒸干,使形成一个均匀的薄膜,加入50ml缓冲液(30%乙醇-pH5.3磷酸缓冲液),搅拌30min,即得。平均包封率为75.06%。结论:该薄膜蒸发法制备醇质体的工艺稳定可行。Objective： To optimize the processing technology of indomethacin ehtosmoes. Methods： The drug dosage, phospholipid dosage, alcohol concentration, stirring time and some other influencing factors were investigated by orthogonal experimental design. Encapsulation rate was token as the evaluation index with SPSS11.5 as the statistical analyzing software. Results： The optimum processing technology was： indomethacin 0.15g and phospholipids 0.5g dissolved with chloroform 10ml,and evaporated to form a film, 40ml buffer （30% ethanol- pH5.3 phosphate buffer was added）, and stirring for 30rain. The average encapsulation rate was 75.06%. Conclusion： The processing technology is stable and feasible.

关 键 词：吲哚美辛 醇质体 制备 薄膜分散法 

分 类 号：R914.2[医药卫生—药物化学]