高纯度罗库溴铵的合成  

Preparation of a Substantially Pure Rocuronium Bromide

作　　者：汪会霞[1] 

机构地区：[1]江苏正大天晴药业股份有限公司,连云港市222000

出　　处：《药学与临床研究》2013年第2期135-137,共3页Pharmaceutical and Clinical Research

摘　　要：以2β,3α,5α,16β,17β)-2-(4-吗啉)-16-(1-吡咯)-雄甾-3,17-二醇为起始原料,经乙酰化、溴丙烯季铵盐化反应得到符合《欧洲药典》标准的高纯度罗库溴铵。（2α, 3α, 5α, 16α, 17α）-2-（4-morpholinyl）-16-（1-pyrrolidinyl）-androstane-3, 17-diol being used as the starting material, via aeetylation and forming quaternary ammonium salt with allyl bromide, a product of substantially pure roeuronium bromide was obtained complying with the European Pharmacopoeia standards.

关 键 词：罗库溴铵 制备 纯度 

分 类 号：R914.5[医药卫生—药物化学]