硒蛋氨酸对食管癌放射抗拒细胞药物耐受性的影响  

Effect of selenomethionine on drug-resistance of human esophageal radioresistance carcinoma cells

作　　者：王艳[1] 邓卫平[1] 杨公利[1] 陈滋华[1] 童强[1] 李胜保[1] 

机构地区：[1]湖北医药学院附属太和医院消化内科,湖北十堰442000

出　　处：《海南医学院学报》2013年第5期630-632,共3页Journal of Hainan Medical University

基　　金：湖北省自然科学基金(2004ABA249)~~

摘　　要：目的:研究硒蛋氨酸对食管癌放射抗拒细胞药物耐受性的影响。方法:以食管癌EC9706细胞为研究对象,建立放射抗拒的食管癌EC9706细胞株EC9706R,研究硒蛋氨酸对EC9706R细胞的影响。结果:EC9706R细胞耐药指数是EC9706细胞的1.24倍,硒蛋氨酸浓度大于4μmol/L时明显降低EC9706R细胞对顺铂的药物耐受性(P<0.05)。结论:硒蛋氨酸对食管癌放射抗拒细胞的药物耐受性具有一定的逆转作用。Objective： To investigate the effect of selenomethionine on the drug-resistance of human esophageal carcinoma radioresistance cells. Methods： Radioresistant cells （EC9706R） were established by means of continuous fractionated gamma-ray irradiation upon human esophageal squamous cancer cell line EC9706. MTT assay was used to detect the effect of Selenomethionine on the drug-resistance of EC9706R. Results： The esophageal cancer radioresistant cells （EC9706R） showed increased cisplatin-resistance. 4μmol/Lselenomethionine had significantly effect on the cisplatin-resistance of EC9706R （P〈0. 05）. Conclusions： Selenomethionine can overcome drug-resistance of esophageal squamous cancer radioresistant cellsn.

关 键 词：食管癌细胞 放射抗拒 硒蛋氨酸 

分 类 号：R735.1[医药卫生—肿瘤]