三唑类杀菌剂的合成工艺及其抑菌性评价  

Synthesis Process and Bacteriostasis of Triazole Compound

作　　者：李靖[1] 刘幸平[1] 程康华[2] 翟炜[2] 崔爱玲[2] 燕乐乐[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]南京林业大学化学工程学院,江苏南京210037

出　　处：《木材工业》2013年第3期21-24,共4页China Wood Industry

基　　金：林业公益性行业专项"水载型复合有机木材防腐剂的研究与开发"(201104032)

摘　　要：三唑类杀菌剂在木材保护中有很大的应用潜力,为了开发一种合成路线短的三唑类杀菌剂——1-(1H-1,2,4-三唑-1-基)-2-叔丁基-3-(4-氯苯氧基)-2-丙醇,探讨原料配比、反应温度和反应时间,对目标化合物产品收率的影响,并检测其抑菌性。结果表明,依据试验得出的优化工艺,合成的目标化合物收率高达62%,目标化合物对所选霉菌和木腐菌均有一定的抑制效果。Triazole fungicide has demonstrated a great potential in wood preservation In order to develop a short synthetic route of triazole fungicides—1（1H1,2,4triazole1yl）2tertbutyl3 （4chlorophenoxy）2propanol, the authors investigated the effects of molar ratio, reaction temperature, and reaction time on the yield of the target compound and evaluated its bacteriostasis The result showed that the yield of the target compound was about 62%, under the mole ratio of 1（2tertbutyl2,3epoxy propyl）1h1,4trichlorobenzene triazole methane sulfonate to pchlorophenol to sodium hydride 1∶12∶138, temperature 60 ℃ for 6 h The target compound also showed promising inhibitory effect on the selected mold and woodrotting fungi.

关 键 词：三唑类化合物 合成工艺 抑菌性 

分 类 号：TQ455[化学工程—农药化工]