非小细胞肺癌患者生活质量评分变化对其生存期的预测作用研究  

Study of relationship between changes in quality of life scores and survival time in patients with non-small cell lung cancer

作　　者：胥常琴[1] 刘艺薇[1] 李燕玮[1] 

机构地区：[1]莱芜市人民医院肿瘤内科,山东莱芜271100

出　　处：《临床肺科杂志》2013年第6期1090-1093,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究非小细胞肺癌患者生活质量评分变化对其生存期的预测作用。方法采用EORTC QLQ-C30法评估280例非小细胞肺癌患者生活质量。并采用Cox回归模型分析患者在治疗前及3个月时两时间点的生活质量参数改变对其生存期的预测意义。结果多变量模型分析发现非小细胞肺癌患者体能、恶心呕吐、失眠症状评分改变与患者生存期之间存在相关(P值均<0.05)。病理分级为Ⅳ期患者,在治疗3个月后体能评分每增加10分,患者死亡率则下降8%(OR=0.92,P<0.05)。结论非小细胞肺癌患者的生活质量参数与其生存期存在相关,对其相关因素的干预能够改善患者的生存期。Objective We investigated whether changes in quality of life could predict survival in non - small cell lung cancer. Methods 280 cases of quality of life was evaluated using EORTC QLQ-C30 （European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire）. Cox regression evaluated the prognostic significance of baseline, 3-month and changes in quality of life scores. Results On muhivariate analysis, some changes among the physical function, roles of the general function or nausea/vomiting and insomnia of the general symptom variables were significantly predictive of survival（ P 〈 0.05 ）. The pathological grade IV patients, physical rating for each additional 10 points after 3 months of treatment, mortality rate decreased by 8% （ OR =0.92 ,P 〈0. 05 ）. Conclu- sion There was a relationship between life quality and survival time in non - small cell lung cancer, and intervene of these factors could improve their survival time.

关 键 词：生命质量 非小细胞肺癌 生存期 预后 

分 类 号：R734.2[医药卫生—肿瘤]