晚期糖基化终末产物受体及其抑制剂的研究进展  

The research progress on RAGE and RAGE inhibitor

作　　者：吕翠[1,2,3] 刘洪娟[1,2,3] 刘晓丽[1,2,3] 张文生[1,2,3] 

机构地区：[1]北京师范大学中药资源保护与利用北京市重点实验室,北京100875 [2]教育部天然药物工程研究中心,北京100875 [3]云南省三七生物技术与制药工程研究中心,云南昆明650000

出　　处：《中国药理学通报》2013年第4期452-456,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274118);科技部"重大新药创制"科技重大专项资助项目(No 2012ZX09103-201);北京市共建资助项目(No 403105)

摘　　要：晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)是一种多配体的膜受体,与配体结合后可启动多条信号通路,引起细胞内氧化应激和炎症反应等,导致细胞功能紊乱。RAGE在糖尿病并发症、炎症、阿尔采末病和肿瘤等疾病的发生和发展中起重要作用。应用可溶性RAGE(sRAGE)、抗RAGE抗体或干扰RAGE与配体结合的抑制剂阻断RAGE的活化,是防治上述疾病的新策略。该文对RAGE配体与疾病的关系和RAGE-配体激活的信号通路进行阐述,并对近年来关于RAGE抑制剂的研究进展进行总结。RAGE（receptor for advanced glycation end products） is a multiligand receptor on the cell surface.Ligand-RAGE interactions activate several signal transduction pathways that propagate cellular oxidative stress and inflammatory response.RAGE has been recognized as a key molecule in the development of severe chronic pathologies,including diabetic complications,chronic inflammation,Alzheimer’s disease,cancer and so on.Blockade of ligand-RAGE interaction with sRAGE,RAGE specific antibody or other RAGE inhibitors can stop the effect that RAGE produces.It is suggested that blockade of the RAGE axis may be a new target for therapeutic intervention in the diseases mentioned above.In this article,we briefly review the relationship between RAGE ligand and disease,the signal transduction pathways activated by ligand-RAGE interactions and summarize the research progress on RAGE inhibitor.

关 键 词：晚期糖基化终末产物受体 配体 疾病 信号转导 炎症反应 氧化应激 抑制剂 

分 类 号：R-05[医药卫生] R392.11