左旋精氨酸在食管癌治疗中的作用  

Effects of L arginine in Patients with Esophageal Carcinoma

作　　者：秦子敏[1] 郅兴义[2] 赵松[2] 

机构地区：[1]河南省肿瘤医院胸外科,郑州市450003 [2]河南医科大学第一附属医院心胸外科

出　　处：《中国肿瘤临床》2000年第8期591-593,共3页Chinese Journal of Clinical Oncology

摘　　要：目的 :探讨左旋精氨酸在食管癌治疗中的作用。方法 :86例患者随机分为两组 ,实验组术前 15天静脉输注左旋精氨酸 0 .5g/kg·天 ,然后手术。标本行细胞凋亡检查 ,与对照组对比。结果 :实验组肿瘤细胞凋亡阳性率明显高于对照组。结论 :左旋精氨酸可引起食管癌细胞的凋亡 。Objective:To study the effects of L arginine for patients with esophageal cancer.Methods:Eighty six patients were randomly divided into two groups:each of 43 cases in experimental group and control group.L arginine was given at 0.5g/kg/d iv for 15 days prior to operation of the experimental group.Apoptosis in these samples were detected by terminal labeling method and compared with control group.Results:It showed that apoptosis cell in experimental group siginificantly increased than that in control group.Conclusion:It suggests that L arginine plays an important role in the treatment of esophageal carcinoma.

关 键 词：食管癌 左旋精氨酸 一氧化氮 细胞凋亡 

分 类 号：R735.1[医药卫生—肿瘤]