脑梗死患者血清腐胺、精脒、精胺水平变化  

Changes in levels of serum polyamines in the patients with cerebral infarction.

作　　者：刘红霞 刘新平 李义召[2] 卢林[2] 李明欣[2] 傅善基[2] 

机构地区：[1]山东省菏泽地区第三人民医院 [2]山东医科大学附属医院

出　　处：《华中医学杂志》2000年第4期173-174,共2页Central China Medical Journal

摘　　要：目的　动态观察脑梗死患者血清腐胺、精脒、精胺水平变化。方法　选择 16例脑梗死患者及 2 6例正常人 ,应用高效液相色谱法测定血清腐胺、精脒、精胺水平。结果　脑梗死患者发病 7天内腐胺水平显著升高并达峰值 ,7天后开始下降 ,14天后仍明显高于对照组 ;精脒、精胺水平 7天内显著低于对照组 ,7天后恢复并逐渐达对照组水平。脑梗死急性期腐胺水平随病情加重显著升高 ,精脒、精胺水平随病情加重而下降。结论　聚胺代谢紊乱参与了脑梗死的病理生理过程。Objective To study the changes in levels of serum polyamines in the patients with cerebral infarction.Methods Serum putrescine,spermidine and spermine were measured by using HPLC in 16 cases of cerebral infarction and 26 controls.Results The levels of serum putrescine in the patients with cerebral infarction were increased as compared with those in the control group.The level of serum putrescine reached its peak within 7 days,began to decrease from the 7th day and higher than in the control group after 14 days.The levels of serum spermidine and spermine in the patients with cerebral infarction were significantly decreased as compared with those in the control group within 7 days,gradually recovered and returned to that in the control group after 7 days.The severer the condition of cerebral infarction,the higher the putrescine level and the lower the spermidine and spermine levels.Conclusion Polyamines metabolic disturbance plays a major role in pathophysiological and pathogenetic mechanisms of cerebral infarction.

关 键 词：脑梗塞 聚胺 府胺 粗脒 精胺 血清 病理生理 

分 类 号：R743.33[医药卫生—神经病学与精神病学]