消化道肿瘤患者抗FTL自身抗体检测及诊断意义  

Diagnostic value of anti-FTL autoantibody in diagnosis of common malignant gastrointestinal tumors

作　　者：王晓蕊[1] 张春霞[1] 任鹏飞[1] 王凯娟[1,2,3] 代丽萍[1,2,3] 王鹏[1,2,3] 张建营[1,2,3] 

机构地区：[1]郑州大学公共卫生学院流行病学教研室,河南郑州450001 [2]郑州大学蛋白质组学研究中心 [3]河南省肿瘤流行病学重点实验室

出　　处：《中国公共卫生》2013年第5期666-668,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(30872962)

摘　　要：目的探讨抗铁蛋白轻链(ferritin light chain,FTL)自身抗体(以下简称FTL抗体)在常见消化道肿瘤诊断中的价值。方法用ELISA法检测消化道癌症患者(食管癌、胃癌、原发性肝癌均为250例),慢性肝病患者(乙肝120例、丙肝54例、肝硬化58例)和113例正常人血清中的FTL抗体,比较不同组间FTL抗体含量及阳性率的差异。结果各癌症组FTL抗体含量均高于正常对照组(均P<0.001),其中肝癌组FTL抗体含量高于食管癌组和胃癌组(均P<0.001);肝癌组FTL抗体含量高于慢性肝病组(P=0.000),慢性肝病组FTL抗体含量高于正常对照组(P=0.000);食管癌、胃癌、肝癌、慢性肝病组FTL抗体阳性率分别为46.8%、48.4%、61.6%、32.3%,均高于正常对照组的0.9%(均P=0.000),其中肝癌组抗体阳性率高于食管癌、胃癌和慢性肝病组(均P<0.01),慢性肝病组抗体阳性率高于正常对照组(χ2=43.738,P=0.000);FTL抗体检测食管癌、胃癌、肝癌的灵敏度分别为46.8%、48.4%、61.6%,特异度均为99.1%。结论 FTL抗体在消化道肿瘤患者体内含量增高,对于诊断消化道肿瘤有一定意义。Objective To evaluate the value of anti-ferritin light chain（FTL） autoantibody in the diagnosis of common malignant gastrointestinal tumors.Methods The serum levels of anti-FTL autoantibody in different groups,including a variety of gastrointestinal tumors（250 esophageal cancer patients,250 gastric cancer patients,250 primary hepatocellular carcinoma（HCC） patients,chronic liver diseases patients（120 hepatitis B patients,54 hepatitis C patients,58 liver cirrhosis patients）,and 113 normal individuals,were measured with enzyme-linked immunosorbent assay（ELISA）,then the content and the positive rate of anti-FTL autoantibody in different groups were analyzed and compared.Results 1.The anti-FTL autoantibody levels in gastrointestinal tumor groups were all significantly higher than normal individuals（all P0.001）.Compared with esophageal cancer patients or gastric cancer patients,the anti-FTL autoantibody levels in primary hepatocellular carcinoma patients were significantly higher（all P0.001）.2.The anti-FTL autoantibody levels in primary hepatocellular carcinoma patients were higher than those with chronic liver diseases（P=0.001）.Further more,the anti-FTL autoantibody levels in those with chronic liver diseases were significantly higher than that of normal individuals（P=0.000）.3.The positive rate of anti-FTL autoantibody in cancer groups was significantly higher than that of normal subjects（all P values were less than 0.001）.4.The sensitivity of anti-FTL autoantibody in the detection of gastrointestinal tumors（esophageal cancer,gastric cancer and HCC）was 46.8%,48.4%,and 61.6%,respectively,and the specificity was 99.1%.Conclusion The concentration of anti-FTL autoantibody increases in gastrointestinal tumor patients and the increase is significant for the the diagnosis of common malignant gastrointestinal tumors.

关 键 词：铁蛋白轻链(FTL) 消化道肿瘤 肿瘤相关抗原 

分 类 号：R735[医药卫生—肿瘤]