梗阻性黄疸血清中白细胞介素8(IL-8)水平的研究  

The serum level of Interleukin-8 in the patients with obstructive Jaundice

作　　者：郑敏[1] 张学文[1] 徐红[2] 郑泽霖[1] 

机构地区：[1]白求恩医科大学第三临床学院基本外科,吉林长春130031 [2]白求恩医科大学第一临床学院镜检科,吉林长春130021

出　　处：《临床肝胆病杂志》2000年第3期168-169,共2页Journal of Clinical Hepatology

摘　　要：为了研究在梗阻性黄疸时机体血清中白细胞介素８（ＩＬ－８）的变化，与正常对照组及单纯胆囊结石组间有无差别，我们采用了双抗体夹心法（ＥＬＩＳＡ）进行测定，结果发现ＩＬ－８水平及检出率在良、恶性梗阻性黄疸组均较正常对照组及单纯胆囊结石组明显增高（Ｐ＜０．0０１）。但良、恶性梗阻性黄疸组间ＩＬ－８水平无明显差异（０．０５＜Ｐ＜０．０１），在良性与恶性梗阻性黄疸中ＩＬ－８参与了梗阻性黄疸肠源性内毒素血症的发病过程。In order to investigate the changes of Interleukin-8 in obstructive jaundice group,gallstone group and control group.The method of ELISA was used to examine the serum levels of Interleukin-8.The results show that the positive rate and the levels of Interleukin-8 are much higher than control group and gallstone group(P<0.01).The levels of Interleukin-8 are not much different in benign obstructive jaundice from malign obstructive jaundice.Interleukin-8 play an important role in the endotoxemia of obstructive jaundice.

关 键 词：梗阻性黄疸 白细胞介素8 血清诊断 ELISA 

分 类 号：R575[医药卫生—消化系统]