肝硬化患者P物质、NO水平与高动力循环的关系  

The relationship between plasma level of substance P,NO and hyperdynamic circulation in patients with cirrhosis

作　　者：李昌平[1] 谭道玉[1] 吉田睛彦 小俣政男[2] 

机构地区：[1]四川省泸州医学院附院,四川泸州646000 [2]日本东京大学医学部

出　　处：《临床肝胆病杂志》2000年第3期169-171,共3页Journal of Clinical Hepatology

摘　　要：本文采用竞争性酶联免疫分析和二步生化比色法测定了６７例肝硬化（ＬＣ）患者、４６例健康人血浆Ｐ物质和一氧化氮（ＮＯ）水平，以及血动力学参数。显示失代偿期ＬＣ患者血浆Ｐ物质、ＮＯ水平较代偿期及正常人为高。失代偿期ＬＣ患者全身血管阻力（ＳＶＲ）、平均动脉压（ＭＡＰ）明显降低，心输出量（ＣＯ）明显增加；ＳVＲ与血浆Ｐ物质、ＮＯ水平呈负相关。提示ＮＯ过度形成和释放是启动和维持ＬＣ门脉高动力循环的重要因素。Ｐ物质对维持门脉高压高动力循环起重要作用。Plasma levels of substance P,Nitric oxide(NO) Were assayed in 67 Patients with cirrhosis and 46 health controls.In addition, systemic and portal hemodynamics were evaulated. Results showed that compared with compensated cirrhosis,decompensated liver cirrhosis(LC) had higher plasma levels of substance P,NO,accompanied by a lower systemic vascular resistance(SVR ),Lower mean arterial pressure(MAP) and increased cardic output(CO);SVR in decompensated LC was correlated with the levels of both substance P and NO. The data above suggested that Excessive formation and release of NO may participate in the initiation and maintenance of hemodynamic derangements in cirrhosis.Substance P may contribute to the maintenance of the hyperdynamic circulation.

关 键 词：P物质 一氧化氮 肝硬化 高动力循环 

分 类 号：R575.2[医药卫生—消化系统]