鼻及副鼻窦内翻性乳头状瘤临床病理及其与预后的关系  

The relationship of clinicopathology and prognosis of inverted papilloma in nose and paranasal sinuses

作　　者：杨景[1] 柳凤轩[1] 

机构地区：[1]第三军医大学附属西南医院病理研究所,重庆400038

出　　处：《第三军医大学学报》2000年第7期688-691,共4页Journal of Third Military Medical University

摘　　要：目的　探讨鼻腔内翻性乳头状瘤临床病理及其与预后的关系。方法　采用组织学观察、多参数统计学分析方法对 43例鼻腔内翻性乳头状瘤的临床特点、病理形态及预后的相关性进行研究。结果　①预后与患者的性别、年龄、病程及肿瘤发生部位无关 (P >0 .0 5 ) ;②对临近骨质的侵犯、瘤细胞不典型增生程度及核分裂像多少与癌变关系密切 (P <0 .0 1) ,但与复发无关 (P >0 .0 5 ) ;③复发患者比不复发患者易于癌变 (P <0 .0 1)。结论　瘤细胞不典型增生、核分裂像可能是预测内翻性乳头瘤癌变的指标。对邻近骨质的侵犯及复发是导致内翻性乳头状瘤癌变的重要因素。Objective To study the relationship of clinical pathology with prognosis of papilloma in the nose and paranasal sinuses.Methods 43 cases of inverted papilloma of the nose and paranasal sinuses were studied histopathologically and its multiple parameters were analyzed statistically.Results The prognosis was not correlated to the sex and age of the patient and the course and site of the tumor ( P >0.05) . The invasion to the adjacent bones, the degree of cellular atypia and the mitotic features were positively correlated to the malignant degeneration of the tumor (P<0.01) but not to the rate of recurrence (P>0.05). A recurrent papilloma was easier to progress than a primary tumor (P< 0.01) . Conclusion Cellular atypia and mitotic features might serve as indices for the malignant degeneration of papilloma. Invasion to the adjacent bones and recurrence after surgery are easy to lead to malignant changes of the tumor.

关 键 词：内翻性乳头状瘤 预后 病理 鼻肿瘤 副鼻窦肿瘤 

分 类 号：R739.62[医药卫生—肿瘤]