阿仑膦酸钠联合化疗对乳腺癌骨转移患者骨代谢的影响  

Effects of Alendronate Combined with Chemotherapy on Bone Metabolism in Patients with Bone Metastasis of Breast Cancer

作　　者：林立忠[1] 林仁志[1] 潘印[1] 

机构地区：[1]台州市中心医院肿瘤外科,浙江台州318000

出　　处：《中国药房》2013年第20期1868-1870,共3页China Pharmacy

摘　　要：目的:观察阿仑膦酸钠联合化疗对乳腺癌骨转移患者骨代谢的影响。方法:选择2009年2月-2012年2月在我院就诊的女性乳腺癌骨转移患者86例,随机均分为试验组和对照组。试验组患者在常规化疗基础上给予阿仑膦酸钠片(每次70mg,每周1次)治疗;对照组患者仅给予常规化疗。两组患者均进行6个疗程化疗。比较两组患者治疗前后Ⅰ型前胶原氨基肽(PⅠNP)、β-胶原特殊序列(β-CTx)、骨特异性碱性磷酸酶(BAP)、骨钙素(OC)和治疗疼痛疗效及不良反应情况。结果:试验组患者治疗后BAP、PⅠNP和OC显著高于治疗前和对照组治疗后,差异均有统计学意义(P<0.01);试验组治疗后β-CTx显著低于治疗前和对照组治疗后,差异有统计学意义(P<0.01);试验组治疗骨痛有效率(90.70%)显著高于对照组(69.77%),差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿仑膦酸钠联合化疗可改善乳腺癌骨转移患者骨代谢指标,减轻骨痛,疗效较好,且不良反应较小。OBJECTIVE：To explore the effect of alendronate combined with chemotherapy on bone metabolism in patients with bone metastasis of breast cancer.METHODS：86 female patients with bone metastasis of breast cancer in our hospital during Feb.2009-Feb.2012 were randomized into trial group and control group.Trial group accepted Alendronate tablet（70 mg,once a week） combined with chemotherapy;control group was given conventional chemotherapy.Both groups received 6 courses of chemotherapy.The procollagen Ⅰ N-terminal propeptide（PⅠNP）,β-crosslaps（β-CTx）,bone alkaline phosphotase（BAP）,steocalein（OC）,pain feeling and adverse drug reactions were compared between 2 groups before and after treatment.RESULTS：After treatment,the concentration of PⅠNP,BAP and OC in trial group were significantly higher than before and in control group after treatment;there was statistical significance（P0.01）.The concentration of β-CTx in trial group was significantly lower than before and in control group after treatment（P0.01）;the effective rate of osteodynia therapy in trial group（90.70%） was significantly higher than in control group（69.77%）;there was statistical significance（P0.05）.There was no statistical significance in adverse drug reactions between 2 groups（P0.05）.CONCLUSIONS：Alendronate combined with chemotherapy improve bone metabolism index and relieve osteodynia in patients with bone metastatics of breast cancer,and it shows good efficacy and slight ADR.

关 键 词：阿仑膦酸钠 化疗 乳腺癌 骨转移 骨代谢指标 疗效 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]