新型席夫碱大环化合物的合成与应用研究  

Synthesis and applications of novel Schiff base macrocyclic compounds

作　　者：苟小锋[1] 刘栋[1] 花成文[1] 王海旗[1] 赵军龙[1] 高学祥[1] 

机构地区：[1]西北大学合成与天然功能分子化学教育部重点实验室,陕西西安710069

出　　处：《化学试剂》2013年第5期396-398,404,共4页Chemical Reagents

摘　　要：以水杨醛、1,2-二溴乙烷、邻苯二胺、对苯二胺、4,4'-二氨基二苯甲烷、4,4'-二氨基二苯醚、联苯胺为原料,经取代、缩合成环,得到一系列新型的席夫碱大环化合物,并对席夫碱大环进行还原,得到结构更稳定,柔韧性更好的仲胺大环。并通过IR、1HNMR和ESI/MS对其结构进行了表征。离子识别研究表明:大环化合物对Na+、Mg2+、Li+无明显作用,对Fe3+和Cu2+有作用。初步生物活性测试表明:席夫碱大环在一定浓度下具有抑菌活性。Several novel Schiff base macrocyclic compounds were synthesized from 1, 2-dibromoethane, diethylamine, salicylaldehyde, o-phenylenediamine, p-phenylenediamine, 4,4＇- diamino-ether, 4, 4＇-diamino-diphenyl methane, and benzidine by substitution and cyclization. In order to obtain more stable, flexibility structures, the Schiff base macrocyclic compounds were reduced to corresponding secondary amine ones. Their structures were confirmed by IR, t HNMR and EIS/MS. Ion identification research shows that： macrocyclic compounds have no obvious function for Na＋, Mg2. and Li ~ ,but have strong effect for Fe3 ＋ and Cu2＋. Preliminary biological activity test indicated that Schiff base macrocyclic compounds have antibacterial activity in a certain concentra- tion.

关 键 词：大环化合物 席夫碱 阳离子识别 抑菌 

分 类 号：O625.5[理学—有机化学] O641.3[理学—化学]