血清前白蛋白和总胆汁酸联合检测在慢性肝病中的临床价值  

Clinical value of detecting serum pre AIB and total bile acid of patients with chronic liver diseases

作　　者：闫明先[1] 王文奇[1] 刘倩[1] 徐昌青[1] 李士玉[1] 

机构地区：[1]山东省千佛山医院,山东济南250014

出　　处：《山东医药》2000年第13期3-4,共2页Shandong Medical Journal

摘　　要：为探讨血清前白蛋白（ＰＡＢ）和总胆汁酸（ＴＢＡ）在慢性肝病中的临床价值，分别检测慢性乙肝（轻度、中度、重度）、肝硬化（代偿期和失代偿期）患者及正常对照组的血清ＰＡＢ、ＴＢＡ及白蛋白（Ａ）、总胆红素（ＴＢＩＬ）水平，并进行分析。结果显示，各型慢性肝病患者血清ＰＡＢ均显著低于对照组（Ｐ＜０．０５或Ｐ＜０．０１），而血清ＴＢＡ则明显高于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。轻、中度慢性乙型肝炎患者的血清ＰＡＢ、ＴＢＡ异常率均高于同组Ａ和ＴＢＩＬ的异常率（Ｐ＜０．０５）。提示联合检测血清ＰＡＢ和ＴＢＡ有助于发现肝脏合成及代谢功能的早期损害。To investigate the clinical value of serum levels of PreAlb(PAB)and total bile acid(TBA)of patients with chronic liver disease,the levels of serum PAB and TBA of patients with chronic hepatitis B and liver cirrhosis were detecled and analyzed,the significance of their changes in different stages of chronic liver disease comparing with the changes of serum albumin(A)and total bilirubin(TBIL)in these patients.The result showed that the serum levels of PAB of these patients were lower,while the levels of TBA were higher significantly than that of healthy controls(P<0.05< or P<0.01)In the patients with early hepatitis B,the changes of serum PAB and TBA were obvious than that of A and TB IL.The results suggest that the serum levels of PAB and TBA can be important markers for predicting the early damage of liver function

关 键 词：慢性肝病 前白蛋白 总胆汁酸 血清诊断 

分 类 号：R575.04[医药卫生—消化系统] R446.112[医药卫生—内科学]