度洛西汀合并认知治疗对抑郁症共病糖尿病患者的疗效  

Efficacy of duloxetine combined with cognitive therapy in the treatment for depression comorbid with diabetes

作　　者：段丽娟[1] 陈红昊[1] 焦清艳[1] 周佳男[1] 

机构地区：[1]天津市安定医院(天津市精神卫生中心),300222

出　　处：《精神医学杂志》2013年第2期138-140,共3页Journal of Psychiatry

摘　　要：目的探讨度洛西汀合并认知治疗对抑郁症共病糖尿病患者的临床疗效及安全性。方法将86例伴有糖尿病的抑郁症患者随机分成度洛西汀合并认知治疗组(研究组)43例,单用度洛西汀组(对照组)43例,疗程8周,于治疗前及治疗第l、2、4、8周末采用汉密尔顿抑郁量表(HAMD),临床总体印象量表(CGI)及治疗中出现的症状量表(TESS)评定临床疗效及不良反应。结果治疗2周末两组HAMD及CGI评分与入组时比较差异均有显著性(P<0.01),研究组在治疗1周末即显现明显疗效(P<0.01);两组间HAMD及CGI评分在治疗第1、2、4、8周末比较差异均有显著性(P<0.01),研究组较对照组下降更显著;研究组有效率81.40%,对照组有效率60.47%,两组疗效有显著性差异(P<0.05);两组不良反应无显著性差异(P>0.05)。结论度洛西汀合并认知治疗可以提高抑郁症共病糖尿病患者疗效,缩短疗程。Objective To explore the efficacy and safety of duloxetine combined with cognitive therapy in the treatment of depression eomorbid with diabetes. Methods 86 depressive patients comorbid with diabetes were randomly assigned into study group treated with duloxetine combined with cognitive therapy and control group treated with duloxetine monotberapy for 8 weeks. The curative effects and adverse reactions were assessed with the Hamilton depression scale （HAMD）, clinical general impression （CGI） and treatment emergent symptom scale （TESS） respectively at baseline and the end of the Ist, 2nd, 4th, 8th week. Results Sores of HAMD and CGI decreased significantly at the end of 2nd week of the treatment in both groups （P 〈 0.01 ）. Therapeutic effect appeared at the end of the I st week in study group （ P 〈 0.01 ）. There were significant differences in scores of HAMD and CGI between the two groups at the end of the 1st, 2nd, 4th, 8th week of the treatment （P 〈0.01 ）. Scores of HAMD and CGI decreased more significantly in study group. There was significant difference in effective rate between study group and control group （ 81.40% vs. 60. 47% , P 〈 0.05 ）, and there was no significant difference in side effects between the two groups （ P 〉 0.05 ）. Conclusion Duloxetine combined with cognitive therapy can promote curative effect and shorten the course in the treatment of depression comorbid with diabetes.

关 键 词：度洛西汀 认知治疗 抑郁症 糖尿病 

分 类 号：R749.4[医药卫生—神经病学与精神病学]