脑内胶质细胞源性神经营养因子及其受体复合物研究进展  

Research progress of glial cell line-derived neurotrophic factor and its receptor complexes in brain

作　　者：陈琳[1] 戴建国[1] 王中立[1] 张绘宇[1] 黄玉芳[1] 赵玉男[1] 

机构地区：[1]南京中医药大学中医脑病重点实验室,江苏南京210023

出　　处：《中国药理学通报》2013年第3期315-318,共4页Chinese Pharmacological Bulletin

基　　金：教育部高等学校博士学科点专项科研基金(No20093237120002);江苏省自然科学基金(NoBK2011815);江苏省高校自然科学基金(No12KJB360008);南京中医药大学青年自然科学基金(No09XZR01)

摘　　要：胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)在脑内广泛分布,通过其受体复合物介导激活细胞内信号转导通路,发挥维持神经元功能和损伤修复等作用。胶质细胞源性神经营养因子家族受体α(GD-NF family receptorα,GFRα)和RET是其受体复合物的主要成员。GDNF和其受体复合物可能参与多种脑部病变的病理生理过程,是潜在的治疗靶点之一。Glial cell line-derived neurotrophic factor（GDNF）,which distributes widely in the brain,possesses potent ability to maintain neural function and restore neural injury by activating intracellular signal transduction pathways via interaction with its receptor complexes.GDNF family receptor α（GFRα） and RET are main members of GDNF receptor complexes.GDNF and its receptor complexes may participate in the pathophysiological processes of some brain diseases,and could be potential therapeutic targets to these diseases.

关 键 词：胶质细胞源性神经营养因子 胶质细胞源性神经营养因子家族受体α RET 受体 信号转导 神经细胞黏附分子 帕金森病 

分 类 号：R-05[医药卫生] R322.81