Hedgehog-Pat/Smo-Gli信号通路介导肿瘤的侵袭转移研究进展  

Research progress on hedgehog-Pat/Smo-Gli signal pathway mediating tumor invasion and metastasis

作　　者：路景涛[1] 何伟[1] 宋莎莎[1] 魏伟[1] 

机构地区：[1]安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室,抗炎免疫药物安徽省工程技术研究中心,安徽合肥230032

出　　处：《中国药理学通报》2013年第5期593-597,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金项目(No 30973543,81173075);高校省级自然科学重点项目(No KJ2012A160)

摘　　要：Hedgehog-Pat/Smo-Gli信号转导通路是一条高度保守的信号转导通路,从果蝇到脊椎动物的胚胎发育、组织分化等特定的过程中,该通路调控着细胞的分化与增殖,发挥着中轴器官的形态发生作用。该通路在肿瘤特别是在上皮类肿瘤发生中同样发挥着重要的作用。近来发现该通路与肿瘤的侵袭转移关系密切。该文就该通路及其在肿瘤侵袭转移中的研究进展作一综述。Hedgehog-Pat/Smo-Gli signal transduction pathway is a highly conservative signal pathway. The pathway regulates and controls the differentiation and proliferation of cells, and plays the role of morphogenesis of the axis organ in biological specific development, including biological embryonic development, tissue differentiation and so on, from drosophila to vertebrate. This pathway also plays an important role in tumorigenesis, especially in tumorigenesis of epithelial cancers. Recently researchs indicated that the pathway closely was associated with invasion and metastasis of tumors. In this paper, we reviewed the research progress of the pathway and its role in invasion and metastasis of tumors.

关 键 词：Hedgehog-Pat Smo-Gli信号通路 胃癌 胰腺癌 膀胱癌 乳腺癌 神经胶质瘤 结肠癌 肝癌 侵袭转移 

分 类 号：R-05[医药卫生] R329.25