细胞内镁离子平衡调节机制研究进展  

Research progress of magnesium ion balance adjusting mechanism within the cell

作　　者：王静[1,2] 洪炳哲[1,2] 

机构地区：[1]遵义医学院,贵州遵义563003 [2]大连大学附属新华医院心内科,辽宁大连116021

出　　处：《中国药理学通报》2013年第5期606-609,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30600240;31070998)

摘　　要：Mg2+是细胞内第二位含量丰富的二价阳离子,与生物体的生理病理变化密切相关,但对其平衡调节的机制还不十分清楚。该文就细胞膜通道TRPM6、TRPM7,转运体Na+/Mg2+交换、Ca2+/Mg2+交换及细胞内ATP、蛋白、线粒体、内质网、细胞核与胞内游离镁离子稳态调节研究进展进行综述以为读者提供一个了解镁离子调节的机会。Mg2＋ is the second rich bivalent cation within the cell, which is closely related to the physiological and pathophysiological change in organism, however, its balance adjustment mechanism is not very clear. This review is about the research progress of the cell membrane channel of TRPM6 and RPM7, the Na＋/Mg2＋ and Ca2＋/Mg2＋ exchange transporter, and the stability adjustment effection of intracellular ATP, protein, mitochondria, endoplasmic reticulum and nucleus on free magnesium ion concentration, so that the reader may get an opportunity to know the regulation of the magnesium ion.

关 键 词：Mg2+ ATP TRPM6 TRPM7 Na+ Mg2+交换 CA2+ Mg2+交换 

分 类 号：R-05[医药卫生] R329.25