接种乙型肝炎疫苗后无/低应答影响因素及对策的研究进展  

Advances in the influential factors and counter measures for non-or poor-responders to inoculation of Hepatitis B vaccine

作　　者：张军楠[1] 方鑫[1] 梁争论[1] 

机构地区：[1]卫生部生物技术产品检定方法及标准化重点实验室,中国食品药品检定研究院,北京100050

出　　处：《微生物学免疫学进展》2013年第2期65-69,共5页Progress In Microbiology and Immunology

基　　金：国家"十二五"重大专项资助项目(2012ZX10004701)

摘　　要：乙型肝炎病毒感染呈世界性流行。接种疫苗是预防和控制乙型肝炎的有效措施。但有1%～10%的人群在接种乙型肝炎疫苗后出现无/低应答,影响疫苗的免疫效果。因此探讨无/低应答的机制及对策,对乙型肝炎的防治具有重要意义。本文针对乙型肝炎疫苗接种后无/低应答的影响因素及其对策的研究进行了综述。Hepatitis B virus infection is a serious public health problem worldwide. Vaccination is the effective method to prevent and control the disease. However, quite a few （ about 1%-10% ） subjects who were vaccinated with Hepatitis B vaccines failed to mount a protective antibody response, as a result immuno-protecive efficacy of Hepatitis B vaccine was partly affected. Therefore, investigating the mechanism of non-or poor-response and the related strategies are important to overcome the problem. This review summarizes the influential factors that might affect the immune response to inoculation of Hepatitis B vaccine and the counter measures to solve the problems.

关 键 词：疫苗 乙型肝炎 抗体 应答 

分 类 号：R186[医药卫生—流行病学]