老年性黄斑变性病因研究新进展  

Advance in etiology of age-related macular degeneration

作　　者：潘俊如[1,2] 余其林[2] 张述[2] 李斌[1] 胡军[1,2] 

机构地区：[1]华中科技大学同济医学院附属同济医院眼科 [2]华中科技大学同济医学院附属同济医院生物医学中心,中国湖北省武汉市430030

出　　处：《国际眼科杂志》2013年第5期905-908,共4页International Eye Science

摘　　要：老年性黄斑变性(age-related macular degeneration,AMD)是发达国家首要致盲眼病,在我国的发病率也呈逐年上升的趋势。AMD主要分为干性(地图样萎缩)及湿性(新生血管性)两类,极大的影响了患者的视功能,晚期AMD常导致严重的中心视力下降甚至失明。作为环境因素与遗传基因共同作用的复杂眼底病变,AMD的明确病因尚不完全清楚,近年来研究指出遗传基因、表观遗传、氧化应激、炎症反应、脉络膜血流动力学等均参与了AMD的病变过程,本文就老年性黄斑变性的可能病因做一系统阐述并重点指出表观遗传调控与眼部疾病特别是AMD的密切联系。Agerelated macular degeneration （AMD） is the most common cause of blindness in developed countries. Meanwhile, over the past decade, the incidence increases year by year in China. AMD is classified as atrophic macular degeneration and exudative macular degeneration, always leading to severe central vision loss even blindness in the late stage of AMD. As a degenerative disorder the pathogenesis of AMD remains unclear. Many possible causative factors have been implicated including oxidative stress, lipofuscin accumulation, chronic inflammation, mutation in the complement system, and dysfunctional ocular microcirculation. This review will shed light on the pathogenesis of the disease, especially elaborate the relationship between epigenetic re.qulation and AMD.

关 键 词：老年性黄斑变性 发病机制 表观遗传调控 

分 类 号：R774.5[医药卫生—眼科]