白藜芦醇对小鼠辐射氧化损伤的保护性研究  

The protective effects of resveratrol on irradiation induced oxidative damage in mice

作　　者：李程程[1] 张恒[1] 吴红英[1] 王营营[1] 黄颂[1] 张珠博 孟爱民[1] 

机构地区：[1]北京协和医学院,中国医学科学院放射医学研究所天津市分子和医学重点实验室,天津300192

出　　处：《陕西医学杂志》2013年第5期515-517,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金海外合作基金(No81129020);国家自然科学基金面上项目(No81072237);天津市重点基金(No11JCZDJC19100);国家973重大专项(No2011CB964800-G)

摘　　要：目的:研究白藜芦醇(Rev)对辐射所致的小鼠氧化损伤的防护作用,探讨其可能作用机制。方法:使小鼠接受亚致死剂量(6Gy)的全身照射(TBI),制备辐射损伤模型。检测辐射损伤小鼠血浆中SOD,Mn-SOD和CAT的活性和骨髓单个核细胞中CAT的活性。结果:①在血浆中,单独给药组Mn-SOD水平低于对照组(P<0.05),总SOD变化不明显;照射给药组与照射组相比,总SOD水平显著上升(P<0.05),说明单独给予白藜芦醇后可以降低Mn-SOD水平,但对总SOD无影响。②骨髓单个核细胞和血浆中,单独给予白藜芦醇后可以显著提高CAT活性(P<0.05);照射给药组与照射组相比CAT活性明显提高(P<0.05)。结论:白藜芦醇对由辐射引起的氧化应激损伤有保护作用,其机制可能与提高相应组织过氧化物酶活性有关。Objective： To study the protective effects of resveratrol on irradiation induced damage in the mice and its probable mechanism. Methods： The mice received 6Gy total body irradiation. The SOD, Mn-SOD, and CAT activity in plasma, and the CAT in the BMMC were detected. Result：（1）The Mn-SOD activity in the Rev group was lower than that in the control group（P〈0.05）, the total SOD had slight variation; Compared to the irradiated mouse, the total SOD activity in the Rev＋ IR group increased significantly（P〈0.05 ）, suggesting that Rev could decrease Mn-SOD activity, but not the total SOD. （2） Rev increased CAT in the plasma and BMMC（P〈0. 05）, compared to the irradiated group, the CAT activity in the Rev＋IR group increased significantly （P〈0.05）. Conclusion： Resveratrol has protective effects on the oxidative damage induced by irradiation exposure, and its mecha- nism is probably to promote the peroxidase activity.

关 键 词：氧化剂 损伤 创伤和损伤 治疗 酚类 治疗应用 动物 实验 小鼠 

分 类 号：R649.9[医药卫生—外科学]