小儿川崎病38例外周血糖皮质激素受体检测及其临床意义  

Study on the glucocorticoid receptors in patients with Kawasaki disease

作　　者：周南[1] 王涛[1] 苏德成[1] 高晓鹏[1] 王娟莉[1] 王嵩[1] 

机构地区：[1]西安市儿童医院心脏内科,西安710002

出　　处：《陕西医学杂志》2013年第5期613-615,共3页Shaanxi Medical Journal

摘　　要：目的:探讨川崎病(KD)急性期外周血糖皮质激素受体(GR)α、β水平的变化,为其选择糖皮质激素(GC)治疗提供理论依据。方法:采用ELISA法检测38例急性期KD患儿静脉注射丙种球蛋白(IVIG)前后血中GRα和GRβ水平,并与20例正常对照组进行比较。结果:IVIG静注前KD患儿GRα水平与对照组比较无显著性差异(P>0.05);IVIG后第3天、7天内,GCRα水平较对照组明显下降(P<0.01)。KD患儿GRβ水平在IVIG治疗前后较对照组显著降低(P<0.01)。KD冠状动脉异常组与冠状动脉正常组治疗前后GRα、GRβ水平比较无显著性差异(P>0.05)。结论:KD急性期及早给予外源性GC,则可以发挥更强的抗炎作用。Objective .. To investigate the change of glucocorticoid receptor including glueocorticoid recep- tor-α （GR-α） and glucocorticoid receptor-β（GR-β） in peripheral blood in patients with Kawasaki disease（KD）, for provide a theoretical basis of the glucocorticoid（GC） therapy. Methods.. The levels of GR-α and GR-β were measured using ELISA respectively in 38 patients with KD before and after IVIG and 20 healthy children（control group）. Re- sults.. There was no difference in the level of GR-α in KD patients and the control group（P〉0.05）, But it was sig- nificantly lower （P 〈 0.01） at 3 and 7 days after intravenous immunoglobulin（IVIG）. Before and after IVIG, the GR-β levels were significantly lower in KD patients than in the control group （P 〈 0.01）. The level of GR-αand GR-;differed between patients with and without dilated coronary arteries. Conclusion： The results suggest that ex- ogenous glucocorticoid can play an important role in the process of anti-inflammatory in the acute KD.

关 键 词：黏膜皮肤淋巴结综合征/血液 受体 糖皮质激素/代谢 儿童 

分 类 号：R725.4[医药卫生—儿科]