H型高血压与老年性脑梗塞的相关性  

Association between H-type Hypertension and Senile Cerebral Infarction

作　　者：侯瑞玲[1] 张爱元[2] 孙秀莲 王曙光[2] 杨春秀 綦佩妍 郭丽娜[1] 宿文荣[1] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊市人民医院心内一科 [3]寿光市妇女儿童医院妇科 [4]寿光市中心医院超声科 [5]开平出入境检验局

出　　处：《潍坊医学院学报》2013年第2期97-99,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨H型高血压与老年脑梗塞的相关性。方法选取潍坊市人民医院2011年10月-2012年10月收治的121例老年（均年龄／〉60岁）原发性高血压（EH）高血压合并脑梗塞患者为研究对象，其中按照高血压同型半胱氨酸（Hey）水平是否≥10μmaoL／L，将其分为H型高血压组（H型组）59例和单纯性高血压组（单纯组）6l例，根据患者颅脑CT或MRI是否有梗塞灶，分为脑梗塞组和非脑梗组。并测三酰甘油（TG）、胆固醇（TC）、低密度脂蛋白（LDL—C）、高密度脂蛋白（HDL-C）等生化指标及收集年龄、性别、吸烟史、饮酒史等流行病学资料。结果脑梗塞组患者的He3，水平显著高于非脑梗组（P〈0．01）；且H型组较单纯组脑梗塞患者病例数高（P〈0．05）；经Person相关性分析示：r=0．25，P〈0．01，说明H型高血压与老年脑梗塞的发病有一定的相关性，可能是老年脑梗塞发生的危险因子。结论H型高血压与老年脑梗塞的的高发生率有关，降低Hey水平可能使我国脑梗死的高发生率得到改善。Objective To investigate the correlation of H type hypertension and senile cerebral infarction. Methods One hun- dred and twenty-one elderly patients（ age≥60 years） were chosen in weifang people~ hospital from October 2011 to October 2012,with es- sential hypertension（EH） and with cerebra infarction as the research objects. According tn the hypertension homocysteine （ Hey } levels （whether was higher than 101.unol/L）,they were classified into H-type hypertension group（ H group,59 cases） and simple hypertension group（ simple group,61 eases） ,according to the patient＇s brain CT or MRI infarct,they were divided into the cerebral infarction group and non-cerebral infarction group. And triacyl glycerol （ TG ）, cholesterol （ TC ）, low-density lipoprotein （ LDL-C ）, high density lipoprotein （ HDL- C） and other biochemical indicators were measured and age, sex, smoking histoo, history of alcohol consumption and other epidemiological data were collected. Results Hey level of cerebral infarction group was significantly higher than that of non-cerebral infarction group（ P 〈 0. 01 ） ;Compared to simple group,the number of cerebral infarction eases in H-type group was higher（ P 〈 0.05 ） ;correlation analysis indica- ted： （r =0. 25 ,P 〈 0.01） , H-type hypertension had correlation with the incidence of se,file eerebral infarction,which might be a risk factor. Conclusion The high incidenee of H-type hypertension is related to senile cerebral infarction,and the incidence of cerebral infarction may be controlled by decrease the level of Hey.

关 键 词：高血压 同型半胱氨酸 H型高血压 脑梗塞 老年 

分 类 号：R743.33[医药卫生—神经病学与精神病学]