上腭原发恶性黑色素瘤伴乳腺转移的临床病理特征及文献复习  

Pathology and clinical features of the palate primary malignant melanoma with breast transfer and literature review

作　　者：蔡媛[1] 蔡云[2] 王楠斌 王哲[3] 

机构地区：[1]宝鸡市中心医院病理科,721000 [2]宝鸡市中心医院消化内科,721000 [3]第四军医大学西京医院病理科,西安710032

出　　处：《临床与实验病理学杂志》2013年第5期486-489,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：陕西省2010年卫生科研基金(2010C12)

摘　　要：目的探讨上腭原发恶性黑色素瘤伴乳腺等多脏器转移病例的临床特点、病理特征及预后。方法回顾性分析1例上腭原发无色素型恶性黑色素瘤伴乳腺、肝脏等多脏器转移病例,并复习相关文献。结果上腭原发无色素型恶性黑色素瘤中瘤细胞形态多样,类似肉瘤样病变伴大量中性粒细胞浸润,转移灶中的瘤组织形态与原发灶不完全一致、胞质有色素,转移至肝脏中的瘤组织形态与肝细胞肝癌较难鉴别。免疫表型:上腭S-100蛋白(+),HMB-45(-);乳腺转移灶中S-100蛋白和HMB-45均(+)。结论上腭原发恶性黑色素瘤伴乳腺等多脏器转移病例少见,易误诊,确诊需密切结合HE形态、免疫表型及病史等。Purpose To investigate the clinicopathological characteristics and prognosis of the palate primary malignant melanoma with breast and other muhiple organ metastasis. Methods A case of palatal primary amelanotic malignant melanoma with breast, liver and multiple organ metastasis was retrospectively studied and the related literatures were reviewed. Results The tumor cells of palate pri- mary amelanotic malignant melanoma was varied which similar to sarcomatous lesions with a large number of neutrophil infiltration. The morphology in the metastatic loci was not entirely consistent with primary lesion, while there were pigments in the cytoplasmic of the tumour cell from metastatic foci. The malignant melanoma metastasized to the liver could not indistingnish from hepatocellular carcino- ma. Immunohistochemically, the tumor cells in the primary lesion were positive for S-100 and negative for HMB-45, while the tumor ceils in the metastatic foci were positive for both. Conclusion The palate primary malignant melanoma with breast and multiple organ metastasis was rare and easily misdiagnosed. The combination of HE, immunohistochemical results and history may necessary for cor- rect diagnosis.

关 键 词：上腭肿瘤 乳腺转移 恶性黑色素瘤 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]