子宫内膜样腺癌MUC1表达及其与ER、PR表达的相关性  

Expression of MUC1 and its correlation with the expression of ER and PR in endometrioid adenocarcinoma

作　　者：赵时梅[1] 罗宇[1] 任传伟[1] 史琳[1] 张安文[1] 

机构地区：[1]广西科技大学医学院病理教研室,柳州545000

出　　处：《临床与实验病理学杂志》2013年第5期497-501,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：广西壮族自治区教育厅科研项目(200911MS285);广西壮族自治区卫生厅自筹经费课题(Z2012600)

摘　　要：目的探讨跨膜型黏蛋白1(Mucin 1,MUC1)在子宫内膜样腺癌中的表达及其与ER、PR的相关性。方法采用免疫组化EnVision法检测56例子宫内膜样腺癌、28例不典型增生性子宫内膜及18例增生性子宫内膜组织中MUC1蛋白的表达,同时检测子宫内膜样腺癌组织中ERα、PR的表达。结果 (1)在增生性子宫内膜、不典型增生性子宫内膜和子宫内膜样腺癌中,MUC1蛋白异质表达率分别为27.8%、71.4%和80.4%,差异有显著性(P=0.000)。(2)子宫内膜样腺癌中,随着患者绝经的发生、组织学分级、分期的提高和肌层浸润加深,MUC1蛋白异质表达率有增加趋势(P>0.05);ERα、PR蛋白表达与组织学分级关系密切(P=0.003,P=0.008),与患者月经状态、肌层浸润、淋巴结转移及手术病理分期无关(P>0.05)。(3)子宫内膜样腺癌中,MUC1蛋白表达与ERα蛋白有的负相关关系,与PR蛋白有部分呈正相关关系,但关系不密切(P>0.05)。结论子宫内膜样腺癌中MUC1蛋白异常表达率显著升高,并且与ERα、PR有相互调节关系。Purpose To investigate the expression of MUC1 in endometrioid adenocarcinoma and the relationship between with ER and PR. Methods The MUC1 protein were examined by immunohistochemistry （EnVision method） in endometrioid adenocarcinoma （n = 56）, endometrial atypical hyperplasia （n = 28 ） and proliferative endometrinm （n = 18 ）. At the same time the ERet protein and PR protein were detected in endometrioid adenocarcinoma with same method. Results （ 1 ） In proliferative endometrium, endometrial a- typical hyperplasia and endometrioid adenocarcinoma, the abnormal expression rate of MUC1 was 27.8% , 71.4% and 80. 4% , re- spectively and it was significant difference （ P = 0. 000 ）. （ 2 ） In endometrioid adenocarcinoma, with the occurrence of menopause, histologic grade, stage enhancement and the muscle layer infiltration deepen, the abnormal expression rate of MUC1 protein have in- creased trends （ P 〉 0. 05 ）. The positive rates of ERc~ and PR protein were related to histological grade （ P = 0. 003, P = 0. 008 ）, but they were not associated with mentrual status, muscle layer infitration, lymph node metastasis and stage （P 〉 0. 05）. （3） In endom- etrioid adenocarcinoma, the expression of MUC1 protein has certain negative correlation relationship with ERa and has some positive correlation with PR, but they were not close correlation （P 〉 0. 05 ）. Conclusions The abnormal expression rate of MUC1 increases significantly in endometrioid adenocarcinoma. MUC1 and ERct, PR has certain mutual regulation relationship.

关 键 词：子宫肿瘤 子宫内膜癌 跨膜型黏蛋白1 雌激素受体 孕激素受体 

分 类 号：R737.33[医药卫生—肿瘤]