一氧化碳中毒并发迟发性脑病的危险因素分析  

Risk factors associated with delayed encephalopathy occurrence in carbon monoxide poisoning

作　　者：郭翔云[1] 李果[1] 赵小峰[1] 康国平[1] 

机构地区：[1]四川省巴中市中心医院急诊科,636000

出　　处：《中国医师进修杂志》2013年第13期21-23,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨一氧化碳（co）中毒并发迟发性脑病（DE）的危险因素。方法回顾性分析249例CO中毒患者的病历资料，记录性别、年龄、CO接触时间、出现中毒症状至就诊时间、中毒后是否合并意识障碍、氧疗方式，采用单因素r检验筛选DE的危险因素，将有统计学意义的变量进行非条件Logistic回归分析。结果年龄和CO接触时间与DE的发生有关，60～75岁年龄段发生DE的风险是3～17岁年龄段的3．236倍，是18～59岁年龄段的2．119倍；CO接触时间≥12h发生DE的风险是〈12h的4．338倍。结论年龄≥60岁和CO接触时间≥12h是DE的独立危险因素。CO中毒的老年患者容易发生DE；及早脱离CO接触是预防DE发生的重要措施。Objective To investigate the risk factors associated with delayed encephalopathy （DE） occurrence in carbon monoxide （CO） poisoning. Methods The clinical data of 249 patients with CO poisoning were retrospectively reviewed. Potential risk factors associated with occurrence of D E, including gender, age, duration of exposure to CO, time interval between onset and arrival in hospital, mental status after onset, oxygen therapy approach, were evaluated by univariate analysis of A~ test and multivariate Logistic regression analysis. Results Age and duration of exposure to CO was significantly related with occurrence of DE in patients with CO poisoning. The occurrence of DE in patients with CO poisoning with age 60 -75 years was 3.236 times and 2.119 times as much as that with age 3 - 17 years and 18 -59 years respectively. Occurrence of DE was 4.338 times in patients with duration of exposure to CO 312 hours compared to that 〈 12 hours. Conclusions Age ~ 60 years and duration of exposure to CO ≥12 hours are independent risk factors for developing D E. Old patients have a inclination to develop D E. To evacuate patients from CO environment timely is important for preventing from DE.

关 键 词：一氧化碳中毒 危险因素 迟发性脑病 

分 类 号：R747.9[医药卫生—神经病学与精神病学] R595.1[医药卫生—临床医学]