P21^(WAF1)基因单核苷酸多态性和东北地区HPV相关宫颈癌的关系  

Relationship between P21^(WAF1) SNPs&HPV Related Cervical Cancer in NE China

作　　者：施鹏[1] 李彤[2] 

机构地区：[1]沈阳医学院附属奉天医院妇产科,辽宁沈阳110024 [2]沈阳市妇婴医院妇产科,辽宁沈阳110024

出　　处：《微生物学杂志》2013年第2期68-71,共4页Journal of Microbiology

摘　　要：研究P21WAF1基因单核苷酸多态性与中国东北地区人群HPV阳性宫颈癌风险的关系。以聚合酶链反应-直接测序的方法分析了340例宫颈癌患者标本P21WAF1基因rs1801270和rs3176352多态性,比较不同基因型与宫颈癌风险的关系。rs3176352多态在宫颈癌患者中的分布和正常对照组差异不显著,与宫颈癌风险无关。rs1801270多态在宫颈癌患者中的分布和正常对照组差异显著,宫颈癌患者中C等位基因频率、CC和AC基因型频率明显高于正常对照组(P<0.05);与携带A等位基因者比较,携带C等位基因者罹患宫颈癌的风险增加1.366 7倍(95%CI:1.112 1～1.679 2)。P21WAF1基因rs1801270多态C等位基因是东北地区人群宫颈癌遗传易感因素。Relationship between P21^WAF1 single nucleotide polymorphism （SNP） and susceptibility to the risk of cer-vical cancer in Chinese from NE region via a hospital-based, case-control was studied. Polymerase chain reaction di-rect sequencing was used to analyze and determine the rs1801270 and rs3176352 polymorphisms of P21^WAF1 gene sam-ples from 340 cases of cervical cancer patients and compared the relationship between different genotypes and the risk of cervical cancer. The results showed that there was no noticeable significant difference between the distribution of rs3176352 polymorphisms in cervical cancer patients and normal control, therefore, had nothing to do with the risk of cervical cancer. While the distribution of rs1801270 polymorphisms in cervical cancer patients and normal control had noticeable significance, and the frequency of C allele and the frequency of CC and AC genotypes in cervical cancer was significantly higher as compared with those in control （P 〈 0.05）. Individuals carrying at least one C allele ten-ded to have an increased risk by 1. 366 7 times for cervical cancer as compared with those with A allele （95% CI： 1. 112 1 ～ 1. 679 2）. Therefore, C allele of rs1801270 polymorphisms in P21^WAF1 gene was risky genetic factors of cervical cancer among Chinese from NE region.

关 键 词：宫颈癌 P21WAF1基因 单核苷酸多态 

分 类 号：R737.33[医药卫生—肿瘤]