原核生物大肠杆菌基因组序列形成核小体能力的预测  

The Prediction of E.coli Genome Sequence Form Nucleosome

作　　者：陈冰[1] 任松叶[1] 赵秀娟[1,2] 蔡禄[1,2] 

机构地区：[1]内蒙古科技大学生物工程与技术研究所,内蒙古包头014010 [2]内蒙古科技大学生物质能源化重点实验室,内蒙古包头014010

出　　处：《信阳师范学院学报（自然科学版）》2013年第2期204-207,300,共5页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(61271448);内蒙古自然科学基金项目(2011MS0504);内蒙古高等学校科研基金项目(NJZY12103)

摘　　要：以大肠杆菌基因组为研究对象,基于体外组装的核小体序列中k-mers频数信息,采用多样性增量结合二次判别算法对核心DNA和连接DNA进行分类预测,整体准确率和相关系数分别达到83.08%和0.619.对大肠杆菌、酵母和人类基因组中核小体定位序列与缺失序列中偏好的k-mers进行了比较,结果表明核小体缺失序列更为保守.A computational model of nucleosome core DNA and linker DNA of E. coli genome were developed by using the method of Increment of Diversity combined with Quadratic Discriminant analysis （ IDQD ）, based on k-mers frequency in sequence. The accuracy and correlation coefficient were 83.08% and 0.619, respectively. The preference of the k-mers of nucleosome core DNA and linker DNA on E. coli ,S. cerevisiae and human genome were compared,the results indicated that the linker DNA was more conservative.

关 键 词：大肠杆菌基因组 核小体定位 k-mers频数 多样性增量 二次判别 

分 类 号：Q34[生物学—遗传学]