硬脂酸改性纳米CaCO_3对当归喷雾干燥粉体的影响研究  

Effect of nano-CaCO_3 modified with by stearic acid on spray drying powder of angelica

作　　者：蒋艳荣[1,2] 张振海[1] 陈小云[2] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学,江苏南京210046

出　　处：《中草药》2013年第9期1122-1127,共6页Chinese Traditional and Herbal Drugs

基　　金：江苏省社会发展科技支撑计划(BE2010756);江苏省中医药科技项目(LZ11065);江苏省高等学校大学生创新训练计划项目(011042004000)

摘　　要：目的研究硬脂酸改性纳米CaCO3,制备疏水性纳米CaCO3并应用于当归喷雾干燥粉体。方法采用硬脂酸对纳米CaCO3进行表面改性,通过活化指数(H)、吸油值、接触角和透射电镜(TEM)、傅里叶变换红外光谱(FTIR)对改性前后纳米CaCO3进行分析和表征。以微粉硅胶和未改性纳米CaCO3为对照,考察改性纳米CaCO3对当归喷雾干燥粉体流动性、吸湿性和有效成分阿魏酸溶出行为的影响。结果 FTIR表明硬脂酸吸附在碳酸钙表面;改性后的纳米CaCO3改善当归喷雾干燥粉体流动性和吸湿性的效果优于微粉硅胶和未改性纳米CaCO3,且不影响阿魏酸体外溶出度。结论经硬脂酸改性后的纳米CaCO3应用于中药喷雾干燥粉体值得进一步研究。Abstract： Objective To prepare hydrophobic nano-CaCO3 modified by stearic acid and to study its application in spray drying power of angelica. Methods The stearic acid was used on the surface characteristic of nano-CaCO3, and the modified and unmodified nano-CaCO3 was analyzed and investigated by means of oil absorption value, activation index （H）, angle of repose, transmission electron microscopy （TEM）, and Fourier transforms infrared （FTIR）. The effect of modified nano-CaCO3 on moisture absorption, fluidity, and in vitro dissolution of ferulic acid in spray drying power of angelica were investigated, comparing with silicon dioxide and unmodified nano-CaCO3. Results FTIR analysis showed that stearic acid has attached to CaCO3 surface. Powder flow and powder moisture absorption were improved in modified nano-CaCO3 and the effect was better than silica dioxide and unmodified nano- CaCO3. The in vitro dissolution of ferulic acid was not affected. Conclusion The application of the nano-CaCO3 modified by stearic acid in the spray drying power of Chinese materia medica deserves to be studied further.

关 键 词：硬脂酸 改性纳米CACO3 未改性纳米CaCO3 阿魏酸 体外溶出度 

分 类 号：R283.3[医药卫生—中药学]