急性缺血性脑卒中后血糖水平和造影剂肾病的相关性分析  

Correlation analysis between glucose levels and contrast-induced nephropathy in patients with acute ischemic stroke

作　　者：付睿[1] 戴威[1] 席春江[1] 赵星辉[1] 黄栋[1] 张彤[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院神经内科,北京100038

出　　处：《中国临床医生杂志》2013年第5期35-37,共3页Chinese Journal For Clinicians

摘　　要：目的研究急性缺血性脑卒中(AIS)患者血糖水平和造影剂肾病(CIN)发生率之间的关系。方法回顾性分析接受动脉溶栓治疗的106例AIS患者,根据术前血糖,将患者分为<7.8mmol/L、7.8～11.1mmol/L、>11.1mmol/L 3组,比较溶栓前3组基线特征,并再次按照有无糖尿病分组,比较不同血糖3组CIN发生率。结果卒中后血糖水平和CIN之间的关系在糖尿病组和非糖尿病组有明显差别。非糖尿病组随着血糖增高,3组CIN发生率分别为11.4%、30.0%和50.0%,差异有显著性(P=0.038)。糖尿病组随着血糖增高,3组CIN发生率分别为20.0%、21.4%和22.2%,差异无显著性(P=0.987)。结论非糖尿病AIS患者高血糖是CIN发生的重要危险因素,这类患者应被视为CIN的高危群体,积极给予合适的预防措施避免CIN的发生。Objective To evaluate relationship between glucose levels and contrast-induced nephropathy （CIN）in pa-tients with acute ischemic stroke（AIS）. Method From January 2006 to December 2011, 106 patients with AIS under-going intra-arterial thrombolysis in Beijing Shijitan Hospital were reviewed retrospectively. Patients were divided into 3 pre-procedural glucose groups ： 〈7.8mmol/L,7.8 - 11.1 mmol/L, 〉 11.1 mmoL/L, baseline characteristics of 3 groups were compared. The patients were subdivided according to established diabetes and without established diabetes. Cor-relation between glucose levels and risk for CIN was calculated. Result The relationship between pre-procedural glu-cose and CIN varied markedly in patients with and without diabetes. There was a strong association between serum glucose and CIN risk in patients without diabetes, CIN rates across the 3 glucose groups from lowest to highest： 11.4%, 30.0%, 50.0% （P=0. 038）, but not in patients with diabetes ：20. 0%, 21.4%, 22.2% （P=0.987）. Conclusion Hyperglycemia in patients with AIS who have no history of diabetes is a important risk factor for CIN. The patients should be considered high-risk groups of CIN . Measures should be performed to prevent CIN.

关 键 词：缺血性卒中 溶栓治疗 血糖 造影剂肾病 

分 类 号：R743[医药卫生—神经病学与精神病学]