8-羟基鸟嘌呤糖苷酶1、环氧合酶2基因多态性与阿尔茨海默病的关系  

Association of the polymorphisms of 8-oxoguaniue gene, cyclooxygenase-2 gene with Alzheimer’s disease

作　　者：肖明跃[1] 王建平[1] 

机构地区：[1]郑州大学第五附属医院神经内科,河南郑州450052

出　　处：《中国现代医生》2013年第14期23-25,共3页China Modern Doctor

基　　金：河南省科技厅科技攻关项目研究基金(112102310114)

摘　　要：阿尔茨海默病是一种慢性进行性神经退行性疾病,为老年痴呆最普遍的一种。目前研究认为遗传因素、环境因素和免疫因素等均参与了AD的病理生理过程。家族性AD多呈常染色体显性遗传,与淀粉样前体蛋白(APP)、早老素1(PS1)、早老素2(PS2)基因突变有关。晚发性AD(LOAD)以及散发性AD(SAD)最主要的遗传危险因子是ApoEε4等位基因,但它只与50%的AD有相关,存在其他遗传危险因子。本文就8-羟基鸟嘌呤糖苷酶1基因、环氧合酶2基因多态性与AD的关系的研究现状及进展做一简要综述。Alzheimer＇s disease is a chronic progressive neurodegenerative disease, which is the most common type of senile dementia. Studies now suggested that genetic, environmental and immune factors were involved in the patho physiology of AD. AD was divided into familial AD（FAD） and sporadic （SAD）. The majority of FAD was autosomal dominant, which was associated with the amyloid precursor protein （APP） gene, presenilinl （PS1） gene and presenilin2 （PS2）. ApoE ε4 allele was the most important genetic risk factor of LOAD and SAD. It was only associated with fifty percent of AD, so there must exist other risk factors. This article made a brief overview of the status and progress of AD.

关 键 词：8-羟基鸟嘌呤糖苷酶1 环氧合酶2 阿尔茨海默病 单核苷酸多态性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]