前列腺癌组织P504S、E-Cadherin和bcl-2蛋白表达及意义  

Significances of P504S,E-Cadherin and bcl-2 protein expression in prostate carcinoma

作　　者：温爽[1] 盖宇[1] 宗华凤[1] 刘志敏[1] 智慧兰[1] 刘天卿[1] 

机构地区：[1]大连市友谊医院病理科,辽宁大连116001

出　　处：《大连医科大学学报》2013年第2期123-126,共4页Journal of Dalian Medical University

基　　金：大连市卫生局立项课题

摘　　要：目的分析前列腺癌中P504S、E-Cadherin和bcl-2蛋白的表达情况,探讨其在前列腺癌诊断及预后判断中的意义。方法应用免疫组织化学(Max Vision)法检测45例前列腺腺泡腺癌、6例前列腺高级别上皮内肿瘤及10例前列腺增生组织中P504S、E-Cadherin和bcl-2蛋白的表达情况。结果 P504S蛋白阳性率前列腺癌组(84.4%)明显高于前列腺高级别上皮内肿瘤组(50.0%)和前列腺增生组(0%)(P<0.05);E-Cadherin蛋白阳性率前列腺癌组(42.2%)和前列腺高级别上皮内肿瘤组(33.3%)明显低于前列腺增生组(100%)(P<0.05);bcl-2蛋白阳性率前列腺癌组(60.0%)明显高于前列腺高级别上皮内肿瘤组(16.7%)和前列腺增生组(20.0%)(P<0.05)。前列腺癌Gleason 8～10分组E-Cadherin蛋白的表达率(31.8%)明显低于2～4分组(83.3%)(P<0.05);8～10分组bcl-2蛋白的表达率(68.2%)明显高于2～4分组(33.3%)(P<0.05)。前列腺癌Gleason8～10分组(18.2%)和5～7分组(17.6%)E-Cadherin蛋白的强阳性表达率明显低于2～4分组(83.3%)(P<0.05)。前列腺癌组P504S蛋白阳性同时E-Cadherin蛋白阴性的比率(51.1%)明显高于前列腺增生组(0%)(P<0.05);前列腺癌组P504S蛋白阳性同时bcl-2阳性的比率(57.8%)明显高于前列腺增生组(0%)(P<0.05)。结论 P504S高表达、bcl-2高表达有助于前列腺癌的诊断;联合检测P504S和E–Cadherin,P504S和bcl-2的表达,可以提高诊断前列腺癌的准确性。Objective To study lhe possibility of P504S, E- Cadherin and bel- 2 protein as a marker to diagnose prostate carcinoma. Methods The expressions of these proteins were deteeted by immunohistoehemistly, （Max Vision） method. Resuits The expression rate of P5O4S in prostate carcinoma group （84.4c%） was significantly higher than high prostate intraepithelial neoplasia group （50. 0% ） and prostate girard proliferion group（0% ） （P 〈0.05）; That of E-Cadherin in prostate carcinoma group （42.2%） and high prostate intraepithelial neoplasia group （33.3%） were significantly lower than prostate gland proliferation group （ 100% ） （P 〈0.05 ） ; That of I）el -2 in prostate carcinoma group （60.0%） was signifieantly higher them high prostate intraepithelial neoplasia group （16.7%） and prostate gland proliferatioH group （20.0%） （P 〈0.05 ）. The expression of E-Cadherin in 8 - 10 score group （31.8%） was signifieantly louver than 2 -4 score group （83.3%） （ P 〈 O. 05） ; The expression of bel -2 in 8 - l0 seore group （68.2%） was signifieantly higher than 2 -4 score group （33.3%） （ P 〈0.05 ）. The strong expression rate of E - Cadherin in 8 - 10 （ 18.2%） and 5 -7 （ 17.6% ） score groups were significantly lower than 2 - 4 score group （ 83.3% ） （ P 〈 0.05 ） Both P504S positive and E - Cadherin negative expression rate in prostate careinoma group （51.1% ） was significantly higher than prostate gland proliferation group （0%） （P 〈 0.05 ）. Both P504S and bcl -2 positive rate in prostate careinoma group （57.8%） was significantly higher than prostate gland pro- liferation group （0%） （P 〈 0.05 ）. Conclusion The high expression of P504S, bcl -2 protein may be helpful to diagnose prostate carcinoma. The diagnosis accurate of prostate carcinoma could be increased by detect the expressions of P504S and E -Cadherin, P504S and bcl -2 proteins.

关 键 词：前列腺癌 免疫组织化学 P504S E-CADHERIN BCL-2 

分 类 号：R737.25[医药卫生—肿瘤]