不同角膜接触镜对人眼Zernike像差的影响  

Effects of different contact lens correction on Zernike aberrations of human eye

作　　者：保金华[1] 贺极苍 毛欣杰[1] 吕帆[1] 

机构地区：[1]温州医学院眼视光学院,325027 [2]New England College of Optometry, Boston,M husetts, 02115, USA

出　　处：《中华实验眼科杂志》2013年第5期482-487,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：国家“十一五”科技支撑计划项目（2007BA118B09）

摘　　要：背景 以往研究分析了角膜接触镜配戴产生的像差变化,但这些变化发生的机制仍不明确.完整理解镜-眼系统引起的波前像差变化原因是进一步改良角膜接触镜的设计、提高视觉矫正质量的基础.目的 通过分析近视患者配戴角膜接触镜状态下的Zernike像差,研究角膜接触镜对人眼光学特性的影响.方法 纳入双眼为近视状态的26例志愿者52眼,等效球镜屈光力为-1.75～-8.50 D,使用WASCA波前像差分析仪分别测量受试眼在未矫正状态、硬性透氧性角膜接触镜（RGP-CL）状态及软性角膜接触镜（Soft-CL）状态的人眼像差.采用重复测量单因素方差分析法比较3种状态下人眼波前像差及Zernike系数间的差异性,采用Pearson相关分析法分析受试眼未矫正状态下各像差与RGP-CL矫正状态或Soft-CL矫正状态下像差变化的关系、未矫正状态下各像差与RGP-CL矫正状态或Soft-CL矫正状态下双眼像差的关系及3种状态下双眼间像差变化的关系. 结果 在未矫正状态、RGP-CL矫正状态下及Soft-CL矫正状态下整眼像差的均方根值（RMS）分别为（0.71±0.30）、（0.54±0.19）、（0.74±0.32） μm,总体比较差异有统计学意义（F=8.758,P＜0.001）.RGP-CL矫正状态下的整眼像差RMS明显低于未矫正状态,差异有统计学意义（t=2.746,P=0.008）,Soft-CL矫正状态下的整眼像差RMS与未矫正状态相比差异无统计学意义（t=0.631,P=0.531）,RGP-CL矫正状态下的整眼像差RMS显著低于Soft-CL矫正状态,差异有统计学意义（t=3.428,P=0.001）.未矫正状态、RGP-CL矫正状态及Soft-CL矫正状态下的3～7阶高阶像差RMS分别为（0.34±0.12）、（0.28±0.12）、（0.40±0.14）μm,差异有统计学意义（F=10.681,P＜0.001）.与未矫正状态相比,RGP-CL矫正状态下的高阶像差RMS略下降,差异无统计学意义（t=1.987,P=0.053）,Soft-CL矫正状态下的高阶像差RMS明显高于未矫正状态,差异有统计学意义（Background Even though the change in wavefront aberrations with correction modality is well documented in the literature,little is known about the underlying mechanism.Complete understanding of the causes responsible for the wavefront change in the combined lens-eye system is important since it provides basic knowledge for further improving the technique to correct refractive error by correcting lenses.Objective The aim of this study was to investigate the influence of refractive correction lens on optical property of the eye by analyzing Zernike aberrations in myopic eyes with contact lens correction.Methods This study was approved by the Ethic Committee of Wenzhou Medical College.Written informed consent was obtained from each subject before entering this study.Zernike aberrations of 52 myopic eyes of 26 subjects with the spherical equivalent-1.75 to-8.50 D were measured using a Hartmann-Shock wavefront sensor.The human eye aberrations were examined at the uncorrected condition,rigid-gas-permeable contact lens （RGP-CL） corrected condition and soft contact lens （Soft-CL） corrected condition.The differences of wavefront aberrations and Zernike coefficients were compared by repeated measurement of single factor variance analysis,and correlation of the aberration changes between uncorrected condition and RGP-CL corrected condition or Sofi-CL corrected condition,between the right eyes and left eyes in different conditions were analyzed by Pearson linear correlation.Results Mean total root-mean-square （tRMS） was （0.71 ± 0.30）μm,（0.54±0.19）μm and （0.74±0.32）μm in the uncorrected condition,RGP-CL corrected condition and Soft-CL corrected condition,with a significant difference （F =8.758,P〈0.001）,and tRMS was significant declined under the RGP-CL corrected condition compared with uncorrected condition （t =2.746,P =0.008）,and tRMS in RGP-CL corrected condition was significantly lower than that in Soft-CL corrected condition （t =3.428,P =0.001）.The high RMS （hRMS） was （0.3

关 键 词：波前像差 Zernike像差 硬性透氧性角膜接触镜 软性角膜接触镜 

分 类 号：R778[医药卫生—眼科]