趋化因子与眼部新生血管性疾病研究进展  

The effects of chemokines in ocular neovascular diseases

作　　者：苏梦茹(综述)[1] 孙晓东(审校)[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,200080

出　　处：《中华实验眼科杂志》2013年第5期517-520,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（30973259）;国家重点基础研究发展计划（973计划）项目（国科发财[2011]116号）

摘　　要：趋化因子是机体内一组具有趋化作用的细胞因子，主要表达于中性粒细胞、单核细胞、巨噬细胞、T淋巴细胞和B淋巴细胞，眼部的组织细胞及免疫活性细胞亦可分泌产生多种趋化因子。研究表明，趋化因子在炎症反应、感染、创伤愈合、免疫调节、血管发生、肿瘤的侵袭和转移等生理病理过程中发挥重要作用。高糖、缺氧、氧化应激等因素刺激眼部组织细胞上调CXC趋化因子、CC趋化因子的表达，参与脉络膜新生血管（CNV）及眼部新生血管性疾病的发展。就趋化因子的基本概念和功能以及其与常见眼部新生血管性疾病，如糖尿病视网膜病变（DR）、年龄相关性黄斑变性（AMD）的关系进行综述。Chemokine is a family of small chemotactic eytokines. Chemokine mainly locates in neutrophile granuloeyte,monocyte, macrophage, T lymphocyte and B lymphocyte, and some cells and immunoactive ceils also secret eytokines. Researches showed that ehemokine plays important roles in many patho-physiological activities, such as inflammatory response, infection procedure, wound healing, regulation of immunity, angiogenesis, invasion and metastases of cancer, etc.. Some chemokine factors, such as hyperglycemia, hypoxia, oxidative stress, stimulate the ocular histioeytes to up-regulate the expressions of CXC ehemokines and CC ehemokines, which participate in the development of choroidal neovascularization and ocular neovaseular diseases. This article reviews current progress in chemokine and the relationship between chemokines and ocular neovascular diseases,especially in diabetic retinopathy （DR） and age-related macular degeneration （AMD） etc..

关 键 词：趋化因子 脉络膜新生血管 糖尿病视网膜病变 年龄相关性黄斑变性 

分 类 号：R771[医药卫生—眼科]