鳞状细胞癌抗原在鼻腔鼻窦鳞癌患者血清中的表达及临床意义  

Expression of squamous cell carcinoma antigen and its clinical significance in the patients with sinonosal squamous carcinoma

作　　者：唐智[1] 王继群[1] 李玉兰[1] 陈勇明[1] 涂智峰[1] 

机构地区：[1]南方医科大学附属顺德第一人民医院耳鼻咽喉科,广东顺德528300

出　　处：《山东大学耳鼻喉眼学报》2013年第2期24-25,共2页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：广东省卫生厅科研基金(B2011312);佛山市医学类科技攻关项目(201208208)

摘　　要：目的探讨鼻腔鼻窦鳞癌患者血清中鳞状细胞癌抗原(SCC Ag)的表达及其临床意义。方法对35例鼻腔鼻窦鳞癌、20例鼻内翻性乳头状瘤和30例鼻息肉患者采用微粒子酶免疫法检测血清SCC值,结合临床资料分析该抗原改变的临床意义。结果鼻腔鼻窦鳞癌、鼻内翻性乳头状瘤、鼻息肉患者SCC阳性率分别为54.29%、35.0%和6.67%,差异有统计学意义(P<0.05);鼻腔鼻窦鳞癌患者的病理分级及临床分期均与SCC有相关关系(P<0.05)。结论检测鼻腔鼻窦鳞癌患者血清SCC表达水平对判断病情、临床分期等有一定的临床意义。Objective To determine the expression of squamous cell carcinoma antigen （SCC） and to explore its clini- cal significance in the patients with sinonosal squamous carcinoma. Methods Serum SCC of 35 patients with sinonosal squamous carcinoma was detected by MEIA, and the clinical characters and the clinical significance of SCC were ana- lyzed. Results It showed that the positive rate of SCC expression was 54.29% in the sinonosal squamous carcinoma group, 35.0% in the nasal inverted papilloma group, and 6.67% in the nasal polyps group （ P 〈 0.05）. The content of SCC was closely related to the clinical stage and pathological grade of sinonosal carcinoma （ P 〈 0.05 ）. Conclusion SCC-Ag is useful in diagnosis and clinical monitoring for sinonasal squamous carcinoma.

关 键 词：鳞状细胞癌抗原 鼻腔鼻窦肿瘤 鳞状细胞癌 

分 类 号：R739.62[医药卫生—肿瘤]