人脑胶质瘤凋亡的原位研究  

Apoptosis in human brain gliomas with different grades of malignancy

作　　者：陈义军[1] 章翔[1] 费舟[1] 顾建文[1] 刘卫平[1] 

机构地区：[1]第四军医大学西京医院全军神经外科研究所,陕西西安710033

出　　处：《第四军医大学学报》2000年第9期1144-1146,共3页Journal of the Fourth Military Medical University

摘　　要：目的　探讨不同恶性程度胶质瘤中凋亡的作用和意义 .方法　应用 TUNEL 技术对 38例胶质瘤的凋亡表达及其意义进行了研究 .其中低恶性胶质瘤 2 0例 ,高恶性 18例 .结果　 TUNEL 阳性细胞在各级别胶质瘤中均有表达 ,其在高分化的 ～ 级胶质瘤的阳性率 (凋亡指数 )明显低于 ～ 级胶质瘤 (2 .8± 0 .5 vs5 .6± 1.2 ,P<0 .0 1) ,其表达强度与胶质瘤的良、恶性程度明显相关 (P<0 .0 1) .结论　不同级别胶质瘤凋亡指数有明显差别 ,TU NEL法可辅助临床判断胶质瘤的良。AIM To evaluate the actions and significance of apoptosis in different grades of gliomas. METHODS The apoptosis index (AI) in 20 cases of low grade gliomas and 18 cases of high grade gliomas was detected by techniques of terminal deoxynucleotibyl transferase (TdT) mediated dUTP nick end labeling (TUNEL). RESULTS TUNEL positive cells were present in all grades of gliomas. The low grade gliomas had a low AI compared with high grade gliomas (2.8±0.5 vs 5.6±1.2, P <0.01). The AI was significantly correlated with the glioma malignancy ( P <0.01). CONCLUSION Apoptotic index may be of value in distinguishing different malignancies of gliomas in clinical practice.

关 键 词：脑胶质瘤 细胞凋亡 原位研究 

分 类 号：R739.41[医药卫生—肿瘤]