二苯并环庚酮的合成  

Synthesis of Dibenzosuberone

作　　者：刘巧云[1] 陈文华[1] 

机构地区：[1]常州工程职业技术学院制药与生物工程技术系,江苏常州213164

出　　处：《中国医药工业杂志》2013年第5期434-435,共2页Chinese Journal of Pharmaceuticals

摘　　要：用亚苄基酞经氢氧化钠水解制得2-苯乙酰基苯甲酸,经Pd/C催化氢化制得2-(2-苯乙基)苯甲酸,再在多聚磷酸作用下环合制得二苯并环庚酮,总收率约83%,纯度99.0%。Dibenzosuberone was synthesized from benzalphthalide by hydrolysis with sodium hydroxide to give 2-phenylacetylbenzoic acid, which was subjected to hydrogenation with Pd-C to give 2- （2-phenylethyl） benzoic acid and followed by cyclization in the presence of PPA with an overall yield of 83 % and 99.0 % purity.

关 键 词：二苯并环庚酮 中间体 亚苄基酞 合成 

分 类 号：O626[理学—有机化学]