硝黄汤鼻饲联合灌肠对ICU重症患者肠屏障功能障碍影响的对比性研究  

Comparative Study on Xiaohuangtang and Nasal Feeding with Enema on ICU Patients with Severe Intestinal Barrier Dysfunction

作　　者：李刘英[1] 郑刚[1] 

机构地区：[1]自贡市第一人民医院,四川自贡643000

出　　处：《辽宁中医杂志》2013年第5期953-955,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：自贡市重点科技计划项目(2011S090)

摘　　要：目的:评价硝黄汤鼻饲联合灌肠对ICU重症患者肠屏障功能障碍的影响。方法:将40例肠屏障功能障碍患者随机分为两组,分别于治疗前及治疗1 d、3 d及5 d观察患者肠鸣音、APACHEⅡ评分,检测DAO、IFABP及内毒素水平,记录患者ICU住院天数,试验组20例,给予一般治疗的基础上,在第1天留取试验标本后即在常规治疗的同时开始给予硝黄汤鼻饲联合灌肠,对照组给予常规治疗。结果:治疗前两组肠鸣音、APACHEⅡ评分、DAO、IFABP及内毒素水平差异无统计学意义(P>0.05);经硝黄汤鼻饲联合灌肠治疗后1 d、3 d、5 d,试验组的肠鸣音、APACHEⅡ评分、DAO、IF-ABP及内毒素水平较对照组明显降低(P<0.05)。结论:硝黄汤鼻饲联合灌肠能改善ICU重症患者肠屏障功能障碍。Objective ： To observe the therapeutic effects of Xiaohuangtang to combine nasal on ICU patients with severe intesti- nal barrier dysfunction. Methods ：40 cases of intestinal barrier dysfunction were randomly divided into two groups. APACHE 11 scores before treatment and 1 d ,3 d and 5 d on patients with severe intestinal barrier were observed. DAO, IFABP and endotoxin levels were detected, recording ICU length of stay. 20 cases in experimental group were given the general treatment. After the first day specimens from the test specimens in the routine treatment was given Xiaohuangtang to combine nasal feeding with enema. The control group received conventional therapy. Results： Tow groups before treatment had no significant difference in bowel sounds, APACHE lI , DAO, IFABP and endotoxin levels （ P 〉 0.05 ） ; after giving Xiaohuangtang to combine nasal feeding with enema on 1 d ,3 d and 5 d, bowel sounds, APACHE I1 , DAO, IFABP and endotoxin levels of the experimental group were lower than those in the control group（ P 〈 0. 05 ）. Conclusion ：Xiaohuangtang combined with nasal feeding with enema can improve ICU patients with severe intestinal battier dysfunction.

关 键 词：硝黄汤 鼻饲联合灌肠 ICU重症患者肠屏障功能障碍 

分 类 号：R574[医药卫生—消化系统]