安庆地区配偶吸烟与脑卒中发生风险的关系  

Evaluation on the association between stroke risk and spouses smoking in Anqing

作　　者：王缓[1] 胡晶晶[1] 吴飞[1] 唐根富[1] 邢厚恂 谢迪[3] 蔡业锋[4] 王滨燕[1] 臧桐华[1] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]连云港市现代心血管病防治研究所,江苏连云港222006 [3]南方医科大学肾病研究所,广东广州510515 [4]广东省中医院神经内科,广东广州510120

出　　处：《中华疾病控制杂志》2013年第5期380-383,共4页Chinese Journal of Disease Control & Prevention

基　　金：中国科技部973项目(2012CB517703)

摘　　要：目的评估中国安庆地区人群配偶吸烟和脑卒中发生风险的相关性。方法 1995-2005年基线调查中,通过问卷调查收集吸烟和其他相关变量。2010-2011年对基线人群进行随访收集脑卒中事件并进行核实。COX比例风险模型估计配偶吸烟与脑卒中的相关性。结果纳入分析16 706人,平均随访(7.0±2.2)人年,共收集231例脑卒中事件。调整性别、年龄、收缩压、体质指数(body mass index,BMI)、饮酒变量后,夫妻都吸烟人群发生脑卒中风险是夫妻都不吸烟人群的1.89倍(RR=1.89,95%CI:1.05～3.39),本人吸烟与配偶吸烟对脑卒中的发生有交互作用(P=0.033);本人吸烟配偶不吸烟人群与夫妻都不吸烟人群相比患脑卒中风险增加(RR=1.33,95%CI:0.93～1.90),但差异无统计学意义。按性别分层本人吸烟与配偶吸烟的交互作用相对危险度男性为2.81(95%CI:0.62～12.85)、女性为1.04(95%CI:0.30～3.64),表明无论男性还是女性本人及配偶都吸烟时可能增加本人患脑卒中风险。结论本研究证实夫妻都吸烟可增加脑卒中发生风险。Objective To study the effect of cigarette smoking among spouses on the risk of stroke incidence among Chinese adult population in Anqing areas.Methods A baseline survey was conducted in 1995-2005.In 2010-2011,all objects of baseline screening were invited to participate in a follow-up study.Stroke cases were confirmed by medical record reviews.Cox proportional hazards model was used to evaluate the association between spouse smoking with the risk of stroke.Results 16 706 Chinese were finally enrolled in the survey.During an average of 7.0 years follow-up,a total of 231 stroke events were documented.Compared to people that both husband and wife are nonsmoking,the multivariate-adjusted relative risks for interaction of husband and wife smoking were 1.89（RR=1.89,95% CI：1.05-3.39） for stroke.The interaction between smoking and spouse smoking was statistically significant（P=0.033）.The risk was increased for strokes（RR=1.33,95% CI：0.93-1.90） among smoking people with a nonsmoking spouse,but the result was not statistically significant.The relative risk（RR） of stroke incidence associated with interaction of husband and wife smoking people were 2.81（95% CI：0.62-12.85） in men and 1.04（95% CI：0.30-3.64） in women.Conclusions This prospective study identified both husband and wife smoking increased the risk of stroke incidence.

关 键 词：吸烟 脑卒中 配偶 

分 类 号：R743.3[医药卫生—神经病学与精神病学]