48例获得性维生素K依赖性凝血因子缺乏症患者的临床分析  

Clinical analysis of acquired deficiencies of vitamin K-dependent coagulation factors in 48patients

作　　者：李大鹏[1] 姜波[1] 许剑辉[1] 陈云飞[1] 张广吉[1] 孙秀娟[1] 白洁[1] 田萌苏[1] 杨仁池[1] 竺晓凡[1] 薛艳萍[1] 

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院急救中心,天津300020

出　　处：《临床血液学杂志》2013年第3期309-311,314,共4页Journal of Clinical Hematology

摘　　要：目的:探讨获得性维生素K依赖性凝血因子缺乏症患者的临床特点和治疗效果。方法:获得性维生素K依赖性凝血因子缺乏症患者48例,分析其病因、临床表现、治疗反应等。结果:获得性维生素K依赖性凝血因子缺乏症患者48例,其中病因明确者28例,以鼠药中毒最常见(17/28例)。所有病例均有不同程度的出血表现,出血部位和程度不一。所有病例应用维生素K治疗有效,治疗时间个体差异较大,部分患者复发(12/37例)。鼠药中毒者治疗时间较长。结论:获得性维生素K依赖性凝血因子缺乏症患者的临床表现和治疗效果个体差异较大。Objective：To clarify the clinical characteristics and the treatment responses of the acquired deiiciencies of vitamin K-dependent coagulation factors. Method： Forty-eight patients were retrospectively reviewed. Their clinical manifestations, etiologies and responses to treatment were analyzed. Result ： In 28 of 48 cases, causes of deficiency of vitamin K-dependent coagulation factors were found, and the most common cause was rodenticides poisoning （17/28）. All of the patients had bleeding manifestations. Vitamin K1 application was effective. The time to treatment response was different among individuals, and some patients underwent relapse（ 12/37 cases）. The treatment duration was longer for patients with rodenticides poisoning. Conclusion：Clinical characteristics and treatment responses of the acquired deficiencies of vitamin K-dependent coagulation factors are different among patients. The treatment duration is longer for patients with rodenticides poisoning. After Vitamin K1 therapy,PT and APTT return to normal significantly.

关 键 词：维生素K缺乏症 凝血酶原时间 活化部分凝血活酶时间 

分 类 号：R591.49[医药卫生—内科学]