CpG岛甲基化表型在血液系统疾病中的研究进展  

Research advances of CIMP in hematological diseases

作　　者：赵晓丽[1] 王小钦[1] 贾晓东[2] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040 [2]上海市疾病预防控制中心

出　　处：《临床血液学杂志》2013年第3期356-359,共4页Journal of Clinical Hematology

基　　金：上海市科学技术委员会医学引导项目(No:114119a8200)

摘　　要：CpG岛甲基化表型（CIMP）最早在1999年被提出,用于描述结肠癌中具有CpG位点异常高甲基化的亚型〔1〕。随后,许多学者致力于CIMP的研究。到目前为止,该表型在结肠癌中研究最多,在胃癌〔2〕、肺癌、肝癌〔3〕、恶性胶质瘤〔4〕、卵巢癌、子宫内膜癌〔5〕、乳腺癌、白血病等肿瘤中也有很多报道〔6-7〕。CpG island methylator phenotype （CIMP） was first proposed to describe a subset of colorectahu mors with an exceptionally high frequency of methylation. So far, the ＂right＂ definition of CIMP is still a highly de bated topic. With the development of research,CIMP is considered as an epigenetic phenomenon in many types of tumors, which characterizes tumor formation and progression. Research advances of CIMP in hematological diseases were reviewed in this article.

关 键 词：CIMP 表观遗传学 白血病 急性 淋巴瘤 骨髓增生异常综合征 

分 类 号：R733.71[医药卫生—肿瘤]