Diastereoselective Synthesis of Arylidene Bis（3-arylamino- acrylates） via One-pot Domino Reactions  

作　　者：Zhenming Liu Lili Zhang Jing Sun Chaoguo Yan 

机构地区：[1]Analysis and Test Center, Yangzhou University, Yangzhou, Jiangsu 225002, China [2]College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

出　　处：《Chinese Journal of Chemistry》2013年第4期479-484,共6页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China （Grant No. 21172189） and the Priority Academic Program Devel- opment of Jiangsu Higher Education Institutions.

摘　　要：The functionalized arylidene bis（3-arylaminoacrylates） were efficiently prepared by FeCl3 catalyzed one-pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2-oxoindolinyl 3-arylaminoacrylates were obtained in moderate yields. ^1H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.The functionalized arylidene bis（3-arylaminoacrylates） were efficiently prepared by FeCl3 catalyzed one-pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2-oxoindolinyl 3-arylaminoacrylates were obtained in moderate yields. ^1H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.

关 键 词：domino reaction electron-deficient alkyne ACRYLATE ISATIN STEREOSELECTIVITY 

分 类 号：TQ433.436[化学工程] S4[农业科学—植物保护]