胃复春联合三联抗幽门螺杆菌治疗慢性萎缩性胃炎合并消化性溃疡的疗效分析  

Clinical Analysis on Triple Therapy of Anti-HP Infection Treatment and Weifuchun for Chronic Atrophic Gastritis Combined with Peptic Ulcer

作　　者：何飞龙 刘富颖 张永力 柳峰 金玉弟 袁金仁 

机构地区：[1]上海市金山区中西医结合医院消化内科,上海201501

出　　处：《现代生物医学进展》2013年第12期2352-2355,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨胃复春联合三联抗幽门螺杆菌(HP)治疗慢性萎缩性胃炎(CAG)合并消化性溃疡(PU)的有效性及安全性。方法:将104例HP阳性的CAG合并PU患者随机分为治疗组和对照组,每组各52例。所有患者均采用三联抗HP疗法:奥克+阿莫西林胶囊+克拉霉素,2周后单独服用奥克,连用4周;治疗组在此基础上加用胃复春治疗,连用4周。观察患者症状改善情况、HP根除率、1年复发率、胃黏膜的慢性炎症程度及治疗期间的不良反应。结果:治疗后,治疗组CAG和PU的总有效率分别为94.2%和92.3%,均显著高于对照组总有效率80.8%和75.0%(P<0.05);联合组HP根除率和1年复发率为86.5%和15.6%,三联组分别为67.3%和37.1%,两组比较差异均有统计学意义(P<0.05);治疗后,两组胃黏膜慢性炎症程度评分均较治疗前显著提高,但治疗组升高程度较对照组更为显著(P<0.05);两组均未见严重不良反应。结论:胃复春联合三联抗HP治疗CAG合并PU疗效优于单用抗HP治疗,提高HP的根治率,降低复发率,且毒副作用少。Objective： To investigate clinical effectiveness and safety of triple therapy of anti-HP infection treatment and weifuchun on chronic atrophic gastritis （CAG） combined with peptic ulcer （PU）. Methods： 104 cases of CAG combined with PU were randomly divided into two groups, including 52 cases in treatment group, and 52 cases in control group. All the cases was treated with omeprazole＋amoxicillin＋ clarithromycin capsule for 2 weeks, then omeprazole was given for 4 weeks, and treatment group was given weifuchun additionally for 4 weeks. The improvement of clinical syptoms, HP eradication rate, 1-year recurrence rate, chronic inflammation degree of gastric mucosa and side effects during treatment were compared. Result：After treatment, the total effective rate for CAG and PU in treatment group were 94.2% and 92.3%, which were significantly higher than 80.8% and 75.0 % in control group （P〈0.05）. There was significant difference on HP eradication rate and 1-year recurrence rate between treatment group and control group （86.5% vs.67.3%, 20.0%vs. 34.2%）（P〈0.05）. After treatment, the chronic inflammation degree of gastric mucosa in both group improved significantly than that before treatment, while the improvement in treatment group was more remarkably than that in control group （P〈0. 05）. There was no serious side effect was found in both groups during treatment. Conclusions： It is more effective for triple therapy of anti-HP infection treatment and weifuchun in the treatment of CAG combined with PU than simple use of triple therapy, and it can obviously increase the HP eradication rate, reduce the recurrence rate and side effects.

关 键 词：萎缩性胃炎 消化性溃疡 幽门螺旋杆菌 三联疗法 胃复春 

分 类 号：R573[医药卫生—消化系统]