溶酶体组织蛋白酶D与中枢神经系统疾病  

Cathepsin D and Central Nervous System Diseases

作　　者：潘青[1] 张智博 

机构地区：[1]南华大学长沙市第一医院,湖南衡阳421001 [2]长沙市第一医院神经内科,湖南长沙410005

出　　处：《现代生物医学进展》2013年第13期2581-2583,共3页Progress in Modern Biomedicine

摘　　要：组织蛋白酶D(cathepsin D,catD)是溶酶体内天门冬氨酸蛋白内切酶,广泛分布于人体组织,在脑组织中则主要定位于神经元和脉络丛上皮细胞,其表达、分布及活性的变化影响着中枢神经系统疾病的发生发展,而平衡catD表达与活性及稳定其基因多态性有利于减少疾病发展的风险。在早期的研究中,catD的功能主要与乳腺癌的浸润和转移有关,而后将其作为雌激素依赖的肿瘤标志物来观察。但近几年的研究发现其在神经元的损伤中发挥着重要作用,说明catD与神经系统疾病也有着非常重要的关系。Cathepsin D（catD） is a lysosomal aspartic endopeptidase abundantly in the human tissues,in the central nervous system（CNS）,catD has been localized with in neurons and choroid plexus epithelium,which of the expression,distribution and changes of the activity affects the occurrence and progress of central nervous system diseases,but even out the expression and activity and stabilize polymorphism of catD will be beneficial to reduce the risk of progress of the disease.Earlier studies suggested that the role of catD main related with the infiltration and metastasis of breast cancer,while in the latter case the role of catD is regarded as the tumor markers.Recent studies find that catD has extremely important role on the injury of neurons,indicating that it has an important relation CNS diseases.

关 键 词：溶酶体 组织蛋白酶D 凋亡 中枢神经系统疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]