丝裂霉素C在治疗翼状胬肉中的临床应用  

Clinical Analysis of Limbal Autograft Transplantation with Mitomycin C Therapy of Pterygium

作　　者：杨建华[1] 张琳[1] 罗立勤[1] 郑利民[1] 杜鹏程[1] 包春华[1] 

机构地区：[1]包头医学院第一附属医院眼科,内蒙古包头014010

出　　处：《中国医药指南》2013年第8期18-19,共2页Guide of China Medicine

摘　　要：目的探讨丝裂霉素C在治疗翼状胬肉中的治疗效果。方法对382例（400眼）采用两种不同术式分两组行手术治疗。Ⅰ组：翼状胬肉切除术＋自体角膜缘干细胞移植术;Ⅱ组：翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C。经过6个月~5年的对比观察。结果两种术式比较：翼状胬肉切除术＋自体角膜缘干细胞移植术119眼,治愈104眼,复发15眼,复发率12.6%;翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C手术281眼,治愈276眼,复发5眼,复发率1.8%。结论翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C治疗翼状胬肉复发率明显低于翼状胬肉切除术＋自体角膜缘干细胞移植术,且术后角、结膜上皮修复快,视力恢复好。Objective Analyze the clinical efficacy of surgical method to treat pterygium by pterygium excision with limbal autograft transplantation with mitomycin C in the operation. Methods 382 （400 eyes）pterygium patients admitted in our hospital, according to different surgical methods were divided into two groups： I group： pterygium excision combined with limbal autograft transplantation, IJ group： pterygium excision with limbal autograft transplantation with mitomycin C in the operation, Followed up for 6 months to 36 months.Record postoperative recurrence of pterygium, corneal epithelial healing time and postoperative visual acuity, Statistical analysis of differences results of each surgical method. Results The comparison of the recurrence rate of different pterygium group： I group （119 eyes） had 15 eyes recurrence ,the recurrence rate was 12.6%; 17 group （281 eyes） had 5 eye recurrence, the recurrence rate of 1.8%. After statistical analysis, the recurrence rate among the two groups has significant difference. Conclusions Pterygium excision with limbal autograft transplantation with mitomycin C in the operation is a better treatment to lower the recurrence rate of pterygium and better improvement visual acuity and corneal epithelial repair.

关 键 词：翼状胬肉 角膜缘干细胞 丝裂霉素C 

分 类 号：R777.33[医药卫生—眼科]